Korean J Otorhinolaryngol-Head Neck Surg.  2019 Jun;62(6):355-360. 10.3342/kjorl-hns.2018.00318.

Two Cases of Seronegative Paraneoplastic Neurologic Syndrome with Opsoclonus Nystagmus

• Bae SH
• Lee JM
• Kim SH

• KMID: 2451618
• DOI: http://doi.org/10.3342/kjorl-hns.2018.00318

Abstract

The dizziness associated with paraneoplastic neurologic syndrome is hard to diagnose clinically because the prevalence of disease is rare, and radiologic and serologic examination result may come out normal. Opsoclonus-myoclonus symdrome is a representative of classical paraneoplastic neurologic syndromes. In this paper, we report 2 cases of paraneoplastic neurologic syndromes with negative serologic auto-antibody test and no brain lesion on MRI. Both cases were eventually diagnosed through PET. Patients with opsoclonus-myoclonus type nystagmus should be evaluated for paraneoplastic neurologic syndrome even if their radiologic and serologic findings are normal.

Keyword

Myoclonus; Nystagmus; Opsoclonus-myoclonus syndrome; Paraneoplastic syndrome, neurologic

MeSH Terms

Brain
Dizziness
Humans
Magnetic Resonance Imaging
Myoclonus
Ocular Motility Disorders*
Opsoclonus-Myoclonus Syndrome
Paraneoplastic Syndromes, Nervous System*
Prevalence