Diabetes Metab J.  2014 Aug;38(4):311-316. 10.4093/dmj.2014.38.4.311.

The Effects of Propofol and Isoflurane on Blood Glucose during Abdominal Hysterectomy in Diabetic Patients

• Behdad S
• Mortazavizadeh A
• Ayatollahi V
• Khadiv Z
• Khalilzadeh S

• KMID: 2174108
• DOI: http://doi.org/10.4093/dmj.2014.38.4.311

Abstract

BACKGROUND
Acute hyperglycemia in the perioperative period is associated with significantly increased complications. In few human studies the effects of propofol and inhalational anesthetic on the glucose metabolism were compared. In this study we evaluated the effect of propofol and isoflurane on blood glucose during abdominal hysterectomy in diabetic patients.
METHODS
After approval by the Ethical Committee and written informed consent, thirty 35 to 65 years old diabetic women underwent for elective abdominal hysterectomy under general anesthesia were studied in this randomized single blind clinical trial study. The plasma glucose was maintained at 100 to 180 mg/dL during the operation. Anesthesia protocol was similar in two groups except maintenance of anesthesia that was with infusion of propofol in the propofol group and with isoflurane in the isoflurane group. Blood glucose level and the rate of insulin intake during surgery compared between two groups.
RESULTS
Mean blood glucose before induction of anesthesia did not have significant difference between two groups, but 60 and 90 minutes after starting the operation blood glucose in the propofol group was significantly lower than isoflurane group. Also with using Repeated Measure test, two groups was significantly different according to blood glucose (P=0.045). Mean of administration of insulin during the surgery did not have significant difference between two groups by using repeated measure test and P=0.271. Also mean of bispectral index in different times during the surgery between two groups didn't have significant difference (P=0.35 repeated measure test).
CONCLUSION
Blood glucose increased during maintenance of anesthesia with isoflurane compared to propofol during the surgery.

Keyword

Blood glucose; Isoflurane; Propofol

MeSH Terms

Anesthesia
Anesthesia, General
Blood Glucose*
Female
Glucose
Humans
Hyperglycemia
Hysterectomy*
Informed Consent
Insulin
Isoflurane*
Metabolism
Perioperative Period
Propofol*
Blood Glucose
Glucose
Insulin
Isoflurane
Propofol

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