Intest Res.
2008 Jun;6(1):85-89.
A Case of Ulcerative Colitis with Prolonged Remission Following Azathioprine-Induced Pancytopenia
- Affiliations
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- 1Department of Internal Medicine, Eulji University College of Medicine, Seoul, Korea. pys1109@eulji.ac.kr
Abstract
- Azathioprine (AZA) is widely used for the treatment of inflammatory bowel disease. Bone marrow suppression is a common side effect with AZA treatment. However, data from AZA trials has indicated that a leukocyte count less than 5,000/mm3 was a good predictor of induction and maintenance of remission. Moreover, there is evidence that eradication of sensitized leukocytes by leukapheresis or bone marrow transplantation improves inflammatory bowel disease. We report a case of a patient who had a chronic relapse of ulcerative colitis requiring the frequent use of systemic steroids, but presented prolonged remission following AZA-induced severe pancytopenia. Also colonoscopy showed accelerated healing of diffuse active ulcers following just recovery from pancytopenia.
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