Korean J Gastroenterol.  2008 Sep;52(3):192-195.

A Case of Acute Pancreatitis Induced by Multiple Drugs in a Patient with Ulcerative Colitis

• Son CN
• Lee HL
• Joo YW
• Lee OY
• Han DS
• Yoon BC
• Choi HS
• Hahm JS

Abstract

Acute pancreatitis is a serious disease with fatality rate up to 15%. We recently experienced a case of acute pancreatitis induced by multiple drugs in a patient with ulcerative colitis. A 20-year-old female visited with abdominal pain and hematochezia and diagnosed of ulcerative colitis. Sulfasalazine and prednisolone were used. However, acute pancreatitis occurred after 4 weeks of treatment with additional azathioprine treatment. Drug-induced pancreatitis was suspected, and she was recovered with conventional therapy for acute pancreatitis. Therefore, it was proposed that acute pancreatitis was induced by azathioprine. However, after the administration of sulfasalazine, pancreatitis relapsed. Furthermore, even the re-administration of 5-ASA and azathioprine induced relapse of acute pancreatitis. We concluded that acute pancreatitis was induced by multiple drugs in this patient with ulcerative colitis.

Keyword

Acute pancreatitis; Ulcerative colitis; Azathioprine; Sulfasalazine; 5-aminosalicylate

MeSH Terms

Acute Disease
Anti-Inflammatory Agents, Non-Steroidal/adverse effects
Antimetabolites/adverse effects
Azathioprine/adverse effects
Colitis, Ulcerative/diagnosis/*drug therapy
Colonoscopy
Female
Humans
Mesalamine/adverse effects
Pancreatitis/*chemically induced/*diagnosis
Sulfasalazine/adverse effects
Tomography, X-Ray Computed
Young Adult