Dement Neurocogn Disord.  2012 Mar;11(1):18-24. 10.12779/dnd.2012.11.1.18.

Can We Further Divide Amnestic Mild Cognitive Impairment Based on the Pattern of Memory Deficit?: A Preliminary Study

Affiliations
  • 1Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. jhlee@amc.seoul.kr

Abstract

BACKGROUND
Mild cognitive impairment (MCI) is considered as a transitional state between normal aging and dementia and can be subdivided into amnestic vs. nonamnestic and single vs. multiple domains types. It is suggested that these clinical subtypes may have different underlying etiologies and outcomes. The amnestic MCI differs in the performance profile on memory testing: retention vs. retrieval deficit. Generally, the retention deficit is attributed to the medial temporal dysfunction and the retrieval deficit to the frontal dysfunction. We tried to determine whether there could be distinctive subtypes available even in the amnestic MCI.
METHODS
Sixty-two patients with amnestic MCI-single domain were included in this retrospective study. They were divided into the retention- vs. the retrieval-deficit groups according to the results of Seoul Verbal Learning Test (SVLT). We compared baseline characteristics including vascular risk factors and neuropsychological profiles. We also measured the medial temporal atrophy (MTA) using a visual rating scale and assessed lacunar infarcts and white matter hyperintensities (WMH).
RESULTS
Of 62 patients, 41 had retention deficit and 21 had retrieval deficit on SVLT. Among baseline clinical and demographic variables, only the frequency of hypertension was higher in the retrieval-deficit group (p=0.005). There were no differences in neuropsychological profiles between the two groups other than a lower immediate recall score in the retention-deficit group (p=0.012) and a higher recognition score in the retrieval-deficit group (p=0.001). Severities of WMH and MTA were not different between the two groups, nor was the number of lacunar infarcts and microbleeds.
CONCLUSIONS
We could not find any significant difference except for the frequency of hypertension between the two subgroups of amnestic MCI, suggesting that there may be no further gain in subdividing a single domain amnestic MCI.

Keyword

Amnestic mild cognitive impairment; Memory; Retention; Retrieval; Medial temporal atrophy; White matter hyperintensities

MeSH Terms

Aging
Atrophy
Dementia
Glutamates
Guanine
Humans
Hypertension
Memory
Memory, Short-Term
Mild Cognitive Impairment
Retention (Psychology)
Retrospective Studies
Risk Factors
Stroke, Lacunar
Verbal Learning
Pemetrexed
Glutamates
Guanine

Cited by  1 articles

Subtypes of Amnestic Mild Cognitive Impairment Based on Memory Impairment Pattern and Its Potential Clinical Significance
Hyun Duk Yang, YoungSoon Yang, Benalfew T. Legesse, SangYun Kim,
Dement Neurocogn Disord. 2012;11(2):59-66.    doi: 10.12779/dnd.2012.11.2.59.


Reference

1. Petersen RC, Smith GE, Waring SC, Ivnik RJ, Tangalos EG, Kokmen E. Mild cognitive impairment: clinical characterization and outcome. Arch Neurol. 1999. 56:303–308.
2. Luis CA, Loewenstein DA, Acevedo A, Barker WW, Duara R. Mild cognitive impairment: directions for future research. Neurology. 2003. 61:438–444.
Article
3. Petersen RC, Doody R, Kurz A, Mohs RC, Morris JC, Rabins PV, et al. Current concepts in mild cognitive impairment. Arch Neurol. 2001. 58:1985–1992.
Article
4. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004. 256:183–194.
Article
5. Busse A, Hensel A, Gühne U, Angermeyer MC, Riedel-Heller SG. Mild cognitive impairment: long-term course of four clinical subtypes. Neurology. 2006. 67:2176–2185.
Article
6. Tierney MC, Szalai JP, Snow WG, Fisher RH, Nores A, Nadon G, et al. Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study. Neurology. 1996. 46:661–665.
Article
7. Lafosse JM, Reed BR, Mungas D, Sterling SB, Wahbeh H, Jagust WJ. Fluency and memory differences between ischemic vascular dementia and Alzheimer's disease. Neuropsychology. 1997. 11:514–522.
Article
8. Traykov L, Baudic S, Thibaudet MC, Rigaud AS, Smagghe A, Boller F. Neuropsychological deficit in early subcortical vascular dementia: comparison to Alzheimer's disease. Dement Geriatr Cogn Disord. 2002. 14:26–32.
Article
9. Traykov L, Baudic S, Raoux N, Latour F, Rieu D, Smagghe A, et al. Patterns of memory impairment and perseverative behavior discriminate early Alzheimer's disease from subcortical vascular dementia. J Neurol Sci. 2005. 229-230:75–79.
Article
10. Stern CE, Corkin S, González RG, Guimaraes AR, Baker JR, Jennings PJ, et al. The hippocampal formation participates in novel picture encoding: evidence from functional magnetic resonance imaging. Proc Natl Acad Sci U S A. 1996. 93:8660–8665.
Article
11. Buckner RL, Raichle ME, Miezin FM, Petersen SE. Functional anatomic studies of memory retrieval for auditory words and visual pictures. J Neurosci. 1996. 16:6219–6235.
Article
12. Kang YW, Na DL. Seoul verbal learning test (SVLT). 2003. Seoul: Human Brain Research & Consulting Co..
13. Kang Y, Na DL, Hahn S. A validity study on the Korean mini-mental state examination (K-MMSE) in dementia patients. J Korean Neurol Assoc. 1997. 15:300–308.
14. Hachinski VC, Iliff LD, Zilhka E, Du Boulay GH, McAllister VL, Marshall J, et al. Cerebral blood flow in dementia. Arch Neurol. 1975. 32:632–637.
Article
15. Jung IK, Kwak DI, Shin DK, Lee MS, Kim JY. A reliability and validity study of Geriatric Depression Scale. J Korean Neuropsychiatr Assoc. 1997. 36:103–112.
16. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry. 1961. 4:561–571.
Article
17. Reisberg B, Ferris SH, de Leon MJ, Crook T. The Global Deterioration Scale for assessment of primary degenerative dementia. Am J Psychiatry. 1982. 139:1136–1139.
Article
18. Morris JC. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology. 1993. 43:2412–2414.
19. Kang YW, Na DL. Seoul neuropsychological screening battery. 2003. Incheon: Human Brain Research & Consulting Co..
20. Kim H, Na DL. Normative data on the Korean version of the Boston Naming Test. J Clin Exp Neuropsychol. 1999. 21:127–133.
21. Meyers JE, Meyers KR. Rey Complex Figure Test and recognition trial: Professional manual. 1995. Lutz FL: Psychological Assessment Resources.
22. Kang YW, Chin JH, Na DL, Lee J, Park JS. A normative study of the Korean version of Controlled Oral Word Association Test (COWAT) in the elderly. Korean J Clin Psychol. 2000. 19:385–392.
23. Lee JH, Kang YW, Na DL. Efficiencies of Stroop Interference Indexes in Healthy Older Adults and Dementia Patients. Korean J Clin Psychol. 2000. 19:807–818.
24. Scheltens P, Leys D, Barkhof F, Huglo D, Weinstein HC, Vermersch P, et al. Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry. 1992. 55:967–972.
Article
25. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA. MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR Am J Roentgenol. 1987. 149:351–356.
Article
26. Scheltens P, Barkhof F, Leys D, Pruvo JP, Nauta JJ, Vermersch P, et al. A semiquantative rating scale for the assessment of signal hyperintensities on magnetic resonance imaging. J Neurol Sci. 1993. 114:7–12.
Article
27. Moon SY, Na DL, Seo SW, Lee JY, Ku BD, Kim SY, et al. Impact of white matter changes on activities of daily living in mild to moderate dementia. Eur Neurol. 2011. 65:223–230.
Article
28. Seo SW, Im K, Lee JM, Kim YH, Kim ST, Kim SY, et al. Cortical thickness in single- versus multiple-domain amnestic mild cognitive impairment. Neuroimage. 2007. 36:289–297.
Article
29. Ganguli M, Dodge HH, Shen C, DeKosky ST. Mild cognitive impairment, amnestic type: an epidemiologic study. Neurology. 2004. 63:115–121.
Article
30. Zola-Morgan S, Squire LR, Amaral DG, Suzuki WA. Lesions of perirhinal and parahippocampal cortex that spare the amygdala and hippocampal formation produce severe memory impairment. J Neurosci. 1989. 9:4355–4370.
Article
31. Squire LR, Zola-Morgan S. The medial temporal lobe memory system. Science. 1991. 253:1380–1386.
Article
32. Duffy JD, Campbell JJ 3rd. The regional prefrontal syndromes: a theoretical and clinical overview. J Neuropsychiatry Clin Neurosci. 1994. 6:379–387.
Article
33. Tekin S, Cummings JL. Frontal-subcortical neuronal circuits and clinical neuropsychiatry: an update. J Psychosom Res. 2002. 53:647–654.
34. Desgranges B, Baron JC, Eustache F. The functional neuroanatomy of episodic memory: the role of the frontal lobes, the hippocampal formation, and other areas. Neuroimage. 1998. 8:198–213.
Article
35. Daselaar SM, Veltman DJ, Rombouts SA, Raaijmakers JG, Jonker C. Neuroanatomical correlates of episodic encoding and retrieval in young and elderly subjects. Brain. 2003. 126:43–56.
Article
36. Bernard FA, Desgranges B, Eustache F, Baron JC. Neural correlates of age-related verbal episodic memory decline: a PET study with combined subtraction/correlation analysis. Neurobiol Aging. 2007. 28:1568–1576.
Article
37. Gabrieli JD, Brewer JB, Desmond JE, Glover GH. Separate neural bases of two fundamental memory processes in the human medial temporal lobe. Science. 1997. 276:264–266.
Article
38. Fernández G, Weyerts H, Schrader-Bölsche M, Tendolkar I, Smid HG, Tempelmann C, et al. Successful verbal encoding into episodic memory engages the posterior hippocampus: a parametrically analyzed functional magnetic resonance imaging study. J Neurosci. 1998. 18:1841–1847.
Article
39. Lepage M, Habib R, Tulving E. Hippocampal PET activations of memory encoding and retrieval: the HIPER model. Hippocampus. 1998. 8:313–322.
Article
40. Nyberg L, McIntosh AR, Houle S, Nilsson LG, Tulving E. Activation of medial temporal structures during episodic memory retrieval. Nature. 1996. 380:715–717.
Article
41. Schacter DL, Wagner AD. Medial temporal lobe activations in fMRI and PET studies of episodic encoding and retrieval. Hippocampus. 1999. 9:7–24.
Article
42. Shallice T, Fletcher P, Frith CD, Grasby P, Frackowiak RS, Dolan RJ. Brain regions associated with acquisition and retrieval of verbal episodic memory. Nature. 1994. 368:633–635.
Article
43. Bernard F, Desgranges B, Platel H, Baron JC, Eustache F. Contributions of frontal and medial temporal regions to verbal episodic memory: a PET study. Neuroreport. 2001. 12:1737–1741.
Article
44. Tulving E, Kapur S, Craik FI, Moscovitch M, Houle S. Hemispheric encoding/retrieval asymmetry in episodic memory: positron emission tomography findings. Proc Natl Acad Sci U S A. 1994. 91:2016–2020.
Article
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