Chonnam Med J.  2012 Aug;48(2):91-95. 10.4068/cmj.2012.48.2.91.

Nosocomial Pseudomonas putida Bacteremia: High Rates of Carbapenem Resistance and Mortality

Affiliations
  • 1Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea. sseungi@gmail.com
  • 2Department of Laboratory Medicine, Chonnam National University Medical School, Gwangju, Korea.
  • 3Department of Internal Medicine, Chonnam National University Medical School, Hwasun, Korea.
  • 4Department of Laboratory Medicine, Chonnam National University Medical School, Hwasun, Korea.

Abstract

Previously, Pseudomonas putida was considered a low-virulence pathogen and was recognized as a rare cause of bacteremia. Recently, however, multidrug-resistant and carbapenem-resistant P. putida isolates have emerged, causing difficult-to-treat nosocomial infections in seriously ill patients. Currently, the outcome of multidrug-resistant or carbapenem-resistant P. putida bacteremia remains uncertain. Here, we report 18 cases of P. putida bacteremia with high rates of carbapenem resistance and mortality. From January 2005 through December 2011, all cases of nosocomial P. putida bacteremia were identified and analyzed at Chonnam National University Hospital and Chonnam National University Hwasun Hospital. Electronic medical records were reviewed retrospectively. Four (22%) and five (23%) of 18 P. putida isolates were resistant to imipenem and meropenem, respectively. Common primary infection sites were central venous catheter (7, 39%), pneumonia (5, 28%), and cholangitis (2, 11%). Fourteen (78%) patients had indwelling devices related to the primary site of infection. The 30-day mortality rate was 39% (7/18): 40% (2/5) in patients with carbapenem-resistant P. putida bacteremia vs. 38% (5/13) in patients with carbapenem-susceptible P. putida bacteremia. Nosocomial P. putida bacteremia showed high resistance rates to most potent beta-lactams and carbapenems and was associated with high mortality rates.

Keyword

Pseudomonas putid; Carbapenems; Drug resistance

MeSH Terms

Bacteremia
beta-Lactams
Carbapenems
Central Venous Catheters
Cholangitis
Cross Infection
Drug Resistance
Electronic Health Records
Humans
Imipenem
Pneumonia
Pseudomonas
Pseudomonas putida
Retrospective Studies
Thienamycins
Carbapenems
Imipenem
Thienamycins
beta-Lactams
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