J Cancer Prev.  2015 Jun;20(2):147-152. 10.15430/JCP.2015.20.2.147.

Alcohol Drinking, Cigarette Smoking and Risk of Colorectal Cancer in the Korean Multi-center Cancer Cohort

• Cho S
• Shin A
• Park SK
• Shin HR
• Chang SH
• Yoo KY

• KMID: 2171340
• DOI: http://doi.org/10.15430/JCP.2015.20.2.147

Abstract

BACKGROUND
The present study aimed to examine the association between cigarette smoking, alcohol consumption and colorectal cancer risk among Korean adults.
METHODS
Data from the Korean Multi-center Cancer Cohort between 1993 and 2005 were analyzed. The study population comprised 18,707 subjects aged older than 20 years old. The subjects were followed until December 31, 2011 (median follow-up of 11.2 years). The Cox proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence intervals of cigarette smoking and alcohol consumption for colorectal cancer risk.
RESULTS
In men, longer duration and higher average amount of alcohol consumption were associated with elevated risk of colorectal cancer (HR 1.93 [1.17-3.18] for > or = 30 years of consumption compared to non-drinkers; HR 2.24 [1.31-3.84] for > or = 30 g/d). Former smokers showed a non-significantly elevated risk of colorectal cancer in men. There was no apparent association between alcohol consumption or cigarette smoking and colorectal cancer risk among women.
CONCLUSIONS
Alcohol consumption was associated with increased colorectal cancer risk among Korean men, and both a longer duration and a higher amount of consumption were associated with elevated risk.

Keyword

Colorectal neoplasms; Smoking; Alcohol drinking; Prospective studies

MeSH Terms

Adult
Alcohol Drinking*
Cohort Studies*
Colorectal Neoplasms*
Female
Follow-Up Studies
Humans
Male
Proportional Hazards Models
Prospective Studies
Smoking*
Tobacco Products*