Cancer Res Treat.  2018 Apr;50(2):474-487. 10.4143/crt.2017.094.

Light Alcohol Drinking and Risk of Cancer: A Meta-Analysis of Cohort Studies

• Choi YJ
• Myung SK
• Lee JH

• KMID: 2411136
• DOI: http://doi.org/10.4143/crt.2017.094

Abstract

PURPOSE
The purpose of this study was to determine whether light alcohol drinking increases the risk of cancer by using a meta-analysis of cohort studies because the newly revised 2015 European Code against Cancer fourth edition on alcohol and cancer was based on critical flaws in the interpretation and citation of the previous meta-analyses.
MATERIALS AND METHODS
PubMed and EMBASE were searched in April, 2016. Two authors independently reviewed and selected cohort studies on the association between very light (≤ 0.5 drink/day), light (≤ 1 drink/day), or moderate drinking (1-2 drinks/day) and the risk of cancer incidence and mortality. A pooled relative riskwith its 95% confidence intervalwas calculated by a random-effects meta-analysis. Main outcome measures were cancer incidence and mortality.
RESULTS
A total of 60 cohort studies from 135 articles were included in the final analysis. Very light drinking or light drinking was not associated with the incidence of most cancers except for female breast cancer in women and male colorectal cancer. Conversely, light drinking was associated with a decreased incidence of both female and male lung cancer significantly and both female and male thyroid cancer marginally significantly. Moderate drinking significantly increased the incidence of male colorectal cancer and female breast cancer,whereas it decreased the incidence of both female and male hematologic malignancy.
CONCLUSION
We found that very light or light alcohol drinking was not associated with the risk of most of the common cancers except for the mild increase in the incidence of breast cancer in women and colorectal cancer in men.

Keyword

Alcohols; Neoplasms; Cancer; Cohort studies; Meta-analysis

MeSH Terms

Alcohol Drinking*
Alcohols
Breast
Breast Neoplasms
Cohort Studies*
Colorectal Neoplasms
Drinking
Female
Hematologic Neoplasms
Humans
Incidence
Lung Neoplasms
Male
Mortality
Outcome Assessment (Health Care)
Thyroid Neoplasms
Alcohols

Figure

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  Fig. 1. Flow diagram of identification of relevant studies.

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  Fig. 2. Association between light alcohol drinking (≤ 1 drink/day) and the risk of female breast cancer in a random-effects meta-analysis. RR, relative risk; CI, confidence interval.

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  Fig. 3. Association between light alcohol drinking (≤ 1 drink/day) and the risk of male colorectal cancer in a random-effects meta-analysis. RR, relative risk; CI, confidence interval.

Reference

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