Biomol Ther.
2013 Jul;21(4):284-289.
Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins
- Affiliations
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- 1Department of Biochemistry, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea. jyolee@hallym.ac.kr
- 2Institute of Natural Medicine, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea.
- 3FrontBio Inc., Chuncheon 200-702, Republic of Korea.
- 4S&D Co., Ltd, Sejong 339-820, Republic of Korea.
- 5Department of Agricultural, Food and Nutritional Science, University of Alberta, Canada T6G 2P5.
- 6Department of Fruit, Vegetable and Cereal Technology, Wroclaw University of Environmental and Life Sciences, Wroclaw 51-630, Poland.
- 7Department of Internal Medicine, Chuncheon Sacred Heart Hospital/Hallym University Medical Center, Chuncheon 200-704, Republic of Korea.
- 8Department of Food and Nutrition, College of Natural Sciences, Hallym University, Chuncheon 200-702, Republic of Korea.
- 9Department of Pharmacology, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea.
- 10Institute of Cell Differentiation and Aging, College of Medicine, Hallym University, Chuncheon 200-702, Republic of Korea.
Abstract
- Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin secretion activity in culture of HIT-T15 cells. PCA had excellent antihyperglycemic activity (in terms of blood glucose level and OGTT) and HbA1c-decreasing activity when compared with glimepiride, a sulfonylurea in db/db mice. In addition, PCA showed efficient protection activity of pancreatic beta cell from cell death in HIT-T15 cell culture and db/db mice. The result showed that PCA had antidiabetic and beta cell-protection activities in pancreatic beta cell culture and db/db mice.
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