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The changes of nociception and the signal molecules expression in the dorsal root ganglia and the spinal cord after cold water swimming stress in mice

Feng JH, Sim SM, Park JS, Hong JS, Suh HW

Several studies have previously reported that exposure to stress provokes behavioral changes, including antinociception, in rodents. In the present study, we studied the effect of acute cold-water (4°C) swimming stress...
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The Roles of Chemokines in Immune Response to Mycobacterial Infection

Paik S, Yang M, Suh HW, Jo EK

Tuberculosis (TB), a global and deadly infectious disease caused by Mycobacterium tuberculosis (Mtb), is manifested with host immune reaction. The balanced regulation between protective immune and pathologic inflammatory responses is...
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The Molecular Signatures of Acute-immobilization-induced Antinociception and Chronic-immobilization-induced Antinociceptive Tolerance

Feng JH, Lee HJ, Suh HW

In the present study, the productions of antinociception induced by acute and chronic immobilization stress were compared in several animal pain models. In the acute immobilization stress model (up to...
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Effector Pathways of Toll-like Receptor-inducible Innate Immune Responses in Macrophages

Jo EK, Suh HW, Park JK

Toll-like receptors (TLR) are well-characterized pattern recognition receptors that can recognize and respond to diverse pathogen-associated or danger-associated molecular patterns during infection. TLR signaling in macrophages triggers in the intracellular...
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Modified toe pulp fillet flap coverage: Better wound healing and satisfactory length preservation

Baek SO, Suh HW, Lee JY

BACKGROUND: Amputation is commonly performed for toe necrosis secondary to peripheral vascular diseases, such as diabetes mellitus. When amputating a necrotic toe, preservation of the bony structure is important for...
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The activation of α₂-adrenergic receptor in the spinal cord lowers sepsis-induced mortality

Kim SS, Park SH, Lee JR, Jung JS, Suh HW

The effect of clonidine administered intrathecally (i.t.) on the mortality and the blood glucose level induced by sepsis was examined in mice. To produce sepsis, the mixture of D-galactosamine (GaLN;...
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Management of Lacrimal Fistula during Epicanthoplasty: A Case Report

Han HH, Suh HW, Kim NH, Park RH, Kim KT, Ahn TJ

Lacrimal fistula (LF) is a rare abnormality of the lacrimal system. Patients with LF are usually asymptomatic, and thus, treatment is unnecessary. During surgery on a patient with LF, the...
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Mitochondrial Control of Innate Immunity and Inflammation

Jin HS, Suh HW, Kim SJ, Jo EK

Mitochondria are key organelles involved in energy production, functioning as the metabolic hubs of cells. Recent findings emphasize the emerging role of the mitochondrion as a key intracellular signaling platform...
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Effect of pertussis toxin pretreated centrally on blood glucose level induced by stress

Suh HW, Sim YB, Park SH, Sharma N, Im HJ, Hong JS

In the present study, we examined the effect of pertussis toxin (PTX) administered centrally in a variety of stress-induced blood glucose level. Mice were exposed to stress after the pretreatment...
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Effect of D-glucose feeding on mortality induced by sepsis

Kim SS, Sim YB, Park SH, Lee JR, Sharma N, Suh HW

Sepsis is the life-threatening response to infection which can lead to tissue damage, organ failure, and death. In the current study, the effect of orally administered D-glucose on the mortality...
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Effect of Sulfonylureas Administered Centrally on the Blood Glucose Level in Immobilization Stress Model

Sharma N, Sim YB, Park SH, Lim SM, Kim SS, Jung JS, Hong JS, Suh HW

Sulfonylureas are widely used as an antidiabetic drug. In the present study, the effects of sulfonylurea administered supraspinally on immobilization stress-induced blood glucose level were studied in ICR mice. Mice...
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The Modulatory Role of Spinally Located Histamine Receptors in the Regulation of the Blood Glucose Level in D-Glucose-Fed Mice

Sim YB, Park SH, Kim SS, Kim CH, Kim SJ, Lim SM, Jung JS, Ryu OH, Choi MG, Suh HW

The possible roles of spinal histamine receptors in the regulation of the blood glucose level were studied in ICR mice. Mice were intrathecally (i.t.) treated with histamine 1 (H1) receptor...
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Repaglinide, but Not Nateglinide Administered Supraspinally and Spinally Exerts an Anti-Diabetic Action in D-Glucose Fed and Streptozotocin-Treated Mouse Models

Sim YB, Park SH, Kang YJ, Kim SS, Kim CH, Kim SJ, Lim SM, Jung JS, Ryu OH, Choi MG, Suh HW

We have recently demonstrated that some anti-diabetic drugs such as biguanide and thizolidinediones administered centrally modulate the blood glucose level, suggesting that orally administered anti-diabetic drugs may modulate the blood...
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Postmarketing Surveillance Study of the Efficacy and Safety of Phentermine in Patients with Obesity

Kim HO, Lee JA, Suh HW, Kim YS, Kim BS, Ahn ES, Roh YJ, Jung SG, Kim JM, Kang MK, Ahn IS, Park YG

BACKGROUND: Obesity is a complex problem that is now considered a chronic metabolic disease. In Korea, phentermine has been widely used for the treatment of obesity in the primary care...
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Antidiabetic and Beta Cell-Protection Activities of Purple Corn Anthocyanins

Hong SH, Heo JI, Kim JH, Kwon SO, Yeo KM, Bakowska-Barczak AM, Kolodziejczyk P, Ryu OH, Choi MK, Kang YH, Lim SS, Suh HW, Huh SO, Lee JY

  • KMID: 2170674
  • Biomol Ther.
  • 2013 Jul;21(4):284-289.
Antidiabetic and beta cell-protection activities of purple corn anthocyanins (PCA) were examined in pancreatic beta cell culture and db/db mice. Only PCA among several plant anthocyanins and polyphenols showed insulin...
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Effect of Cholera Toxin Administered Supraspinally or Spinally on the Blood Glucose Level in Pain and D-Glucose Fed Animal Models

Sim YB, Park SH, Kang YJ, Kim SS, Kim CH, Kim SJ, Jung JS, Ryu OH, Choi MG, Choi SS, Suh HW

In the present study, the effect of intrathecal (i.t.) or intracerebroventricular (i.c.v.) administration with cholera toxin (CTX) on the blood glucose level was examined in ICR mice. The i.t. treatment...
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The Efficacy and Safety of a Combined Alendronate and Calcitriol Agent (Maxmarvil): A Postmarketing Surveillance Study in Korean Postmenopausal Women with Osteoporosis

Suh HW, Kim HO, Kim YS, Sunwoo S, Lee JA, Lee HR, Kim B, Kim DH, Choi YS, Cheong YS, Yum K, Yang YJ, Yu BY, Cho CH, Park SB, Shin DH, Korea Post-Marketing Surveillance Research Group

BACKGROUND: Combined therapy with alendronate and calcitriol may have additive effects on bone density. An observational study was performed to evaluate the efficacy and safety of Maxmarvil, a combinative agent...
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Hop Extract Produces Antinociception by Acting on Opioid System in Mice

Park SH, Sim YB, Kang YJ, Kim SS, Kim CH, Kim SJ, Seo JY, Lim SM, Suh HW

In the present study, the antinociceptive profiles of hop extract were characterized in ICR mice. Hop extract administered orally (from 25 to 100 mg/kg) showed an antinociceptive effect in a...
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The Usefulness of the Endonasal Incisional Approach for the Treatment of Nasal Bone Fracture

Kim HS, Suh HW, Ha KY, Kim BY, Kim TY

BACKGROUND: Among all facial fractures, nasal bone fractures are the most common, and they have been reduced by closed reduction (CR) for a long time. But several authors have reported...
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Effect of Agrimonia pilosa Ledeb Extract on the Antinociception and Mechanisms in Mouse

Park SH, Sim YB, Kang YJ, Lee JK, Lim SS, Suh HW

In the present study, the antinociceptive profiles of Agrimonia pilosa Ledeb extract were examined in ICR mice. Agrimonia pilosa Ledeb extract administered orally (200 mg/kg) showed an antinociceptive effect as...
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