Biomol Ther.
2014 Nov;22(6):558-562. 10.4062/biomolther.2014.064.
Dependence Potential of Tramadol: Behavioral Pharmacology in Rodents
- Affiliations
-
- 1Pharmacological Research Division, Toxicological Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungju 361-709, Republic of Korea. hosa33@korea.kr
- 2School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
- 3Department of Infectious Diseases, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.
- KMID: 2170599
- DOI: http://doi.org/10.4062/biomolther.2014.064
Abstract
- Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance and is not generally considered addictive in Korea. In this study, we examined the dependence potential and abuse liability of tramadol as well as its effect on the dopaminergic and serotonergic systems in rodents. In animal behavioral tests, tramadol did not show any positive effects on the experimental animals in climbing, jumping, and head twitch tests. However, in the conditioned place preference and self-administration tests, the experimental animals showed significant positive responses. Taken together, tramadol affected the neurological systems related to abuse liability and has the potential to lead psychological dependence.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Dependence Potential of Quetiapine: Behavioral Pharmacology in Rodents
- The Effects of Tramadol on Electroencephalographic Spectral Parameters and Analgesia in Rats
- Tramadol as a Voltage-Gated Sodium Channel Blocker of Peripheral Sodium Channels Na v 1.7 and Na v 1.5
- Potential for Dependence on Lisdexamfetamine - In vivo and In vitro Aspects
- The Effect of Intrathecal Tramadol and Clonidine on Saddle Block with Heavy Bupivacaine
