- Animal Pain Models and Behavior Tests
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Park JY
- KMID: 2168186
- Hanyang Med Rev.
- 2011 May;31(2):103-106.
- doi: 10.7599/hmr.2011.31.2.103
Animal pain models are essential for understanding the mechanism of pain and development of effective therapy for its management. Various animal pain models have been developed to simulate the clinical... -
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- Use of Behavioral Analysis in Animal Models for Schizophrenia Research
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Woo Y, Lee S, Jeong J, Park SK
- KMID: 2288295
- Korean J Schizophr Res.
- 2014 Apr;17(1):12-26.
- doi: 10.16946/kjsr.2014.17.1.12
Animal models are useful tools to study the molecular basis of schizophrenia pathophysiology and efficacy of potential therapeutic agents. Schizophrenia animal models can be subdivided into three classes ; drug-induced... -
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- Desynchronization of Theta Oscillations in Prefrontal Cortex during Self-stimulation of the Medial Forebrain Bundles in Mice
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Hwang E, Lee H, Choi JH
- KMID: 2416245
- Exp Neurobiol.
- 2018 Jun;27(3):181-188.
- doi: 10.5607/en.2018.27.3.181
Stimulation of the medial forebrain bundle (MFB) can reinforce intracranial self-stimulation (ICSS) in rodents (i.e., reward-seeking behavior). The MFB stimulation produces a highly reliable behavioral output that enabled a clear... -
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- Canine behavioral problems and their effect on relinquishment of the Jindo dog
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Kim YM, Kim SA, Lee SM, Choi YJ, Kim BJ, Shin NS
- KMID: 1072185
- J Vet Sci.
- 2010 Dec;11(4):345-350.
- doi: 10.4142/jvs.2010.11.4.345
The purpose of this study was to evaluate behavior problems of the Jindo dog, the native dog of Korea, based on an owner's survey and their effect on pet relinquishment.... -
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- Biological Rhythm in Livestock
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Giuseppe P, Giovanni C
- KMID: 1095114
- J Vet Sci.
- 2002 Sep;3(3):145-157.
The animal time structure is a basic fact of life, no matter if one wants to study it or not. The time- dependent, mostly rhythmic, and thus to a certain... -
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- Imaging and analysis of genetically encoded calcium indicators linking neural circuits and behaviors
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Oh J, Lee C, Kaang BK
- KMID: 2450491
- Korean J Physiol Pharmacol.
- 2019 Jul;23(4):237-249.
- doi: 10.4196/kjpp.2019.23.4.237
Confirming the direct link between neural circuit activity and animal behavior has been a principal aim of neuroscience. The genetically encoded calcium indicator (GECI), which binds to calcium ions and... -
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- Dependence Potential of Quetiapine: Behavioral Pharmacology in Rodents
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Cha HJ, Lee HA, Ahn JI, Jeon SH, Kim EJ, Jeong HS
- KMID: 2170677
- Biomol Ther.
- 2013 Jul;21(4):307-312.
Quetiapine is an atypical or second-generation antipsychotic agent and has been a subject of a series of case report and suggested to have the potential for misuse or abuse. However,... -
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- Unique Hippocampal Changes and Allodynia in a Model of Chronic Stress
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Kim SH, Moon IS, Park IS
- KMID: 2158046
- J Korean Med Sci.
- 2013 Jun;28(6):946-950.
- doi: 10.3346/jkms.2013.28.6.946
Sustained stress can have numerous pathologic effects. There have been several animal models for chronic stress. We tried to identify the changes of pain threshold and hippocampus in a model... -
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- Behavioral Characteristics of a Mouse Model of Cancer Pain
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Lee BH, Seong J, Kim UJ, Won R, Kim J
- KMID: 1734052
- Yonsei Med J.
- 2005 Apr;46(2):252-259.
- doi: 10.3349/ymj.2005.46.2.252
Pain is a major symptom in cancer patients, and most cancer patients with advanced or terminal cancers suffer from chronic pain related to treatment failure and/or tumor progression. In the... -
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- C-fos Expression in Brain Stem of Rats after Salicylic Acid Treatment
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Kim SC, Jun BH, Choi IS, Jung BJ, Kim DS
- KMID: 2275882
- Korean J Otolaryngol-Head Neck Surg.
- 2002 Mar;45(3):214-218.
BACKGROUND AND OBJECTIVES: Subjective tinnitus, a distracting internal noise, is experienced by humans. Tinnitus is evoked by salicylic acid treatment in rats as confirmed by Jastreboff in 1994 in an... -
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- Development of a Rat Model of Graded Contusive Spinal Cord Injury Using a Pneumatic Impact Device
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Yeo SJ, Hwang SN, Park SW, Kim YB, Min BK, Kwon JT, Suk JS
- KMID: 2157688
- J Korean Med Sci.
- 2004 Aug;19(4):574-580.
- doi: 10.3346/jkms.2004.19.4.574
An animal model of spinal cord trauma is essential for understanding the injury mechanisms, cord regeneration, and to aid the development of new therapeutic modalities. This study focused on the... -
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- Effect of the Combined Use of Tramadol and Milnacipran on Pain Threshold in an Animal Model of Fibromyalgia
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Kim SH, Song J, Mun H, Park KU
- KMID: 1717965
- Korean J Intern Med.
- 2009 Jun;24(2):139-142.
- doi: 10.3904/kjim.2009.24.2.139
BACKGROUND/AIMS: Acidic saline injections produce mechanical hyperresponsiveness in male Sprague-Dawley rats. We investigated the effect of milnacipran in conjunction with tramadol on the pain threshold in an acidic saline animal... -
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- Effects of Different Concentrations of Formalin on Paw Edema and Pain Behaviors in Rats
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Lee IO, Jeong YS
- KMID: 2157599
- J Korean Med Sci.
- 2002 Feb;17(1):81-85.
- doi: 10.3346/jkms.2002.17.1.81
The aim of this study was to determine whether formalin reliably provokes a paw edema and pain behavior. The paw of male Sprague-Dawley rats were injected with 100 microliter of... -
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- Dependence Potential of Tramadol: Behavioral Pharmacology in Rodents
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Cha HJ, Song MJ, Lee KW, Kim EJ, Kim YH, Lee Y, Seong WK, Hong SI, Jang CG, Yoo HS, Jeong HS
- KMID: 2170599
- Biomol Ther.
- 2014 Nov;22(6):558-562.
- doi: 10.4062/biomolther.2014.064
Tramadol is an opioid analgesic agent that has been the subject of a series of case reports suggesting potential for misuse or abuse. However, it is not a controlled substance... -
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- Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice
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Lee SH, Heo Y, Kim YC
- KMID: 1106155
- J Vet Sci.
- 2010 Mar;11(1):35-41.
- doi: 10.4142/jvs.2010.11.1.35
Historically, German chamomile (GC) oil has been used for treatment of skin disorders. BALB/c mice were sensitized twice a week with 100 microL of 1% 2,4-dinitrochlorobenzene (DNCB) and challenged twice... -
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- Analgesic Effects of Dexmedetomidine in Vincristine-Evoked Painful Neuropathic Rats
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Park HJ, Kim YH, Koh HJ, Park CS, Kang SH, Choi JH, Moon DE
- KMID: 2157955
- J Korean Med Sci.
- 2012 Nov;27(11):1411-1417.
- doi: 10.3346/jkms.2012.27.11.1411
Dexmedetomidine, which is a selective alpha2-adrenoceptor agonist, was recently introduced into clinical practice for its analgesic properties. The purpose of this study was to evaluate the effects of dexmedetomidine in... -
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- Tamoxifen Mimics the Effects of Endogenous Ovarian Hormones on Repeated Seizures Induced by Pentylenetetrazole in Rats
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Mansouri S, Ataei ML, Hosseini M, Bideskan A
- KMID: 1427109
- Exp Neurobiol.
- 2013 Jun;22(2):116-123.
- doi: 10.5607/en.2013.22.2.116
In the present study, the effects of tamoxifen on pentylenetetrazole (PTZ)-induced repeated seizures and hippocampal neuronal damage in ovariectomized rats were investigated. Thirty seven virgin female Wistar rats were divided... -
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- Effects of Repetitive Transcranial Magnetic Stimulation on Behavioral Recovery during Early Stage of Traumatic Brain Injury in Rats
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Yoon KJ, Lee YT, Chung PW, Lee YK, Kim DY, Chun MH
- KMID: 2344185
- J Korean Med Sci.
- 2015 Oct;30(10):1496-1502.
- doi: 10.3346/jkms.2015.30.10.1496
Repetitive transcranial magnetic stimulation (rTMS) is a promising technique that modulates neural networks. However, there were few studies evaluating the effects of rTMS in traumatic brain injury (TBI). Herein, we... -
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- Interaction of Morphine and Selective Serotonin Receptor Inhibitors in Rats Experiencing Inflammatory Pain
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Lee BS, Jun IG, Kim SH, Park JY
- KMID: 2157905
- J Korean Med Sci.
- 2012 Apr;27(4):430-436.
- doi: 10.3346/jkms.2012.27.4.430
Citalopram and paroxetine are selective serotonin reuptake inhibitors and also have antinociceptive effects. We investigated the antiallodynic and antihyperalgesic effects of intrathecally administered morphine, citalopram, paroxetine, and combinations thereof, in... -
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- Intrathecal Gabapentin Increases Interleukin-10 Expression and Inhibits Pro-Inflammatory Cytokine in a Rat Model of Neuropathic Pain
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Lee BS, Jun IG, Kim SH, Park JY
- KMID: 1429210
- J Korean Med Sci.
- 2013 Feb;28(2):308-314.
- doi: 10.3346/jkms.2013.28.2.308
We examined the possible anti-inflammatory mechanisms of gabapentin in the attenuation of neuropathic pain and the interaction between the anti-allodynic effects of gabapentin and interleukin-10 (IL-10) expression in a rat... -
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