Infect Chemother.  2011 Dec;43(6):458-467. 10.3947/ic.2011.43.6.458.

Trend of Bacterial Resistance for the Past 50 Years in Korea and Future Perspectives - Gram-negative Bacteria

• Lee K

• KMID: 2170357
• DOI: http://doi.org/10.3947/ic.2011.43.6.458

Abstract

The increasing prevalence of antimicrobial-resistant bacteria has become a serious problem in many parts of the world, including Korea. The resistance of of Gram-positive cocci was once considered to be a more serious problem, but the recent emergence of multi-resistant Gram-negative bacilli has raised great concerns. In Korea, the prevalence of ESBL-producing Escherichia coli and Klebsiella pneumoniae and fluoroquinolone-resistant E. coli, K. pneumoniae, Acinetobacter spp., and Pseudomonas aeruginosa has gradually increased. The increase in imipenem resistance was slight in P. aeruginosa, but drastic in Acinetobacter spp. It is certain that problematic antimicrobial-organism combinations are prevalent in Korea, increase of resistant bacteria will continue in the future. The development of new antimicrobial agents is considered difficult. Therefore, it is very important to use existing antimicrobial agents prudently, to extend the efficacy, to prevent infections, and tostrengthen infection control measures to prevent spread of resistant bacteria.

Keyword

Bacterial resistance; Gram-negative bacteria; Korea

MeSH Terms

Acinetobacter
Anti-Infective Agents
Bacteria
Escherichia coli
Gram-Negative Bacteria
Gram-Positive Cocci
Imipenem
Infection Control
Klebsiella pneumoniae
Korea
Pneumonia
Prevalence
Pseudomonas aeruginosa
Anti-Infective Agents
Imipenem

Figure

• 

  Figure 1 Antimicrobial resistance (%) of E. coli and K. pneumoniae. FUQ, fluoroquinolone; CTX, cefotaine; FOX, cefoxitin; AMK, amikacin.

• 

  Figure 2 Increasing imipenem resistance at Korean hospitals.

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