Clin Pediatr Hematol Oncol.  2009 Apr;16(1):49-53.

A Case of Hemophagocytic Syndrome Induced by Adenovirus Infection after Splenectomy

Affiliations
  • 1Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a rare but sometimes fatal disease. Its main features are prolonged fever, hepatosplenomegaly, cytopenias, and hemophagocytosis in the bone marrow, lymph nodes and other tissues. Hemophagocytic lymphohistiocytosis comprises two different conditions which are: primary, that is with a genetic etiology and secondary, associated with infections, malignancies, and autoimmune diseases. Infection associated hemophagocytic syndrome (IAHS) is caused by bacteria, parasites, fungi, but mostly viruses. A 24 year-old-male, was diagnosed with anaplastic large cell lymphoma and underwent chemotherapy for 6 years because of CNS relapse and leukemic transformation. Thrombocytopenia and splenomegaly persisted after chemotherapy. A splenectomy was done for the treatment of hypersplenism which developed after chemotherapy for anplastic large cell lymphoma, CNS relapse and leukemic transformation. We present a case of hemophagocytic syndrome induced by adenovirus infection after splenectomy.

Keyword

Hemophagocytic lymphohistiocytosis; Adenovirus; Anaplastic large cell lymphoma; CNS relapse; Hypersplenism; Splenectomy

MeSH Terms

Adenoviridae
Adenoviridae Infections
Autoimmune Diseases
Bacteria
Bone Marrow
Fever
Fungi
Hypersplenism
Lymph Nodes
Lymphohistiocytosis, Hemophagocytic
Lymphoma, Large B-Cell, Diffuse
Lymphoma, Large-Cell, Anaplastic
Parasites
Recurrence
Splenectomy
Splenomegaly
Thrombocytopenia
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