Allergy Asthma Immunol Res.  2015 Jul;7(4):359-366. 10.4168/aair.2015.7.4.359.

Effect of Traffic-Related Air Pollution on Allergic Disease: Results of the Children's Health and Environmental Research

• Jung DY
• Leem JH
• Kim HC
• Kim JH
• Hwang SS
• Lee JY
• Kim BJ
• Hong YC
• Hong SJ
• Kwon HJ

• KMID: 2166683
• DOI: http://doi.org/10.4168/aair.2015.7.4.359

Abstract

PURPOSE
This study evaluated the relationship of living near to main roads to allergic diseases, airway hyperresponsiveness (AHR), allergic sensitization, and lung function in Korean children.
METHODS
A total of 5,443 children aged 6-14 years from 33 elementary schools in 10 cities during 2005-2006 were included in a baseline survey of the Children's Health and Environmental Research. We assessed association of traffic-related air pollution (TAP) exposure with the distance to the nearest main road, total road length of main roads and the proportion of the main road area within the 200-m home area.
RESULTS
Positive exposure-response relationships were found between the length of the main road within the 200-m home area and lifetime wheeze (adjusted prevalence ratio [PR] for comparison of the longest to the shortest length categories=1.24; 95% CIs, 1.04-1.47; P for trend=0.022) and diagnosed asthma (PR=1.42; 95% CIs, 1.08-1.86; P for trend=0.011). Living less than 75 m from the main road was significantly associated with lifetime allergic rhinitis (AR), past-year AR symptoms, diagnosed AR, and treated AR. The distance to the main road (P for trend=0.001), the length of the main road (P for trend=0.041), and the proportion of the main road area (P for trend=0.006) had an exposure-response relationship with allergic sensitization. A strong inverse association was observed between residential proximity to the main load and lung function, especially FEV1, FEV1/FVC, and FEF25-75. The length of the main road and the proportion of the main road area were associated with reduced FEV1 in schoolchildren.
CONCLUSIONS
The results of this study suggest that exposure to traffic-related air pollution may be associated with increased risk of asthma, AR, and allergic sensitization, and with reduced lung function in schoolchildren.

Keyword

Air pollution; asthma; allergic rhinitis; respiratory function tests; bronchial hyperreactivity; child

MeSH Terms

Air Pollution*
Asthma
Bronchial Hyperreactivity
Child
Surveys and Questionnaires
Humans
Lung
Prevalence
Respiratory Function Tests
Rhinitis

Reference

1. van Vliet P, Knape M, de Hartog J, Janssen N, Harssema H, Brunekreef B. Motor vehicle exhaust and chronic respiratory symptoms in children living near freeways. Environ Res. 1997; 74:122–132.

2. Nicolai T, Carr D, Weiland SK, Duhme H, von Ehrenstein O, Wagner C, et al. Urban traffic and pollutant exposure related to respiratory outcomes and atopy in a large sample of children. Eur Respir J. 2003; 21:956–963.

3. Wjst M, Reitmeir P, Dold S, Wulff A, Nicolai T, von Loeffelholz-Colberg EF, et al. Road traffic and adverse effects on respiratory health in children. BMJ. 1993; 307:596–600.

4. Ciccone G, Forastiere F, Agabiti N, Biggeri A, Bisanti L, Chellini E, et al. SIDRIA Collaborative Group. Road traffic and adverse respiratory effects in children. Occup Environ Med. 1998; 55:771–778.

5. Hirsch T, Weiland SK, von Mutius E, Safeca AF, Gräfe H, Csaplovics E, et al. Inner city air pollution and respiratory health and atopy in children. Eur Respir J. 1999; 14:669–677.

6. Brunekreef B, Janssen NA, de Hartog J, Harssema H, Knape M, van Vliet P. Air pollution from truck traffic and lung function in children living near motorways. Epidemiology. 1997; 8:298–303.

7. Gauvin S, Amro S, Zmirou D, Le Moullec Y, Sahraoui F, Pin I, et al. Road traffic, NO2 exposure and respiratory function among children (VESTA study). Int J Vehicle Des. 2001; 27:251–261.

8. Holguin F, Flores S, Ross Z, Cortez M, Molina M, Molina L, et al. Traffic-related exposures, airway function, inflammation, and respiratory symptoms in children. Am J Respir Crit Care Med. 2007; 176:1236–1242.

9. Oftedal B, Brunekreef B, Nystad W, Madsen C, Walker SE, Nafstad P. Residential outdoor air pollution and lung function in schoolchildren. Epidemiology. 2008; 19:129–137.

10. Gauderman WJ, Vora H, McConnell R, Berhane K, Gilliland F, Thomas D, et al. Effect of exposure to traffic on lung development from 10 to 18 years of age: a cohort study. Lancet. 2007; 369:571–577.

11. Lee YL, Shaw CK, Su HJ, Lai JS, Ko YC, Huang SL, et al. Climate, traffic-related air pollutants and allergic rhinitis prevalence in middle-school children in Taiwan. Eur Respir J. 2003; 21:964–970.

12. Morgenstern V, Zutavern A, Cyrys J, Brockow I, Gehring U, Koletzko S, et al. Respiratory health and individual estimated exposure to traffic-related air pollutants in a cohort of young children. Occup Environ Med. 2007; 64:8–16.

13. Morgenstern V, Zutavern A, Cyrys J, Brockow I, Koletzko S, Krämer U, et al. Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children. Am J Respir Crit Care Med. 2008; 177:1331–1337.

14. Shima M, Nitta Y, Adachi M. Traffic-related air pollution and respiratory symptoms in children living along trunk roads in Chiba Prefecture, Japan. J Epidemiol. 2003; 13:108–119.

15. Janssen NA, Brunekreef B, van Vliet P, Aarts F, Meliefste K, Harssema H, et al. The relationship between air pollution from heavy traffic and allergic sensitization, bronchial hyperresponsiveness, and respiratory symptoms in Dutch schoolchildren. Environ Health Perspect. 2003; 111:1512–1518.

16. McConnell R, Berhane K, Yao L, Jerrett M, Lurmann F, Gilliland F, et al. Traffic, susceptibility, and childhood asthma. Environ Health Perspect. 2006; 114:766–772.

17. Kim JJ, Smorodinsky S, Lipsett M, Singer BC, Hodgson AT, Ostro B. Traffic-related air pollution near busy roads: the East Bay Children's Respiratory Health Study. Am J Respir Crit Care Med. 2004; 170:520–526.

18. Kim JJ, Huen K, Adams S, Smorodinsky S, Hoats A, Malig B, et al. Residential traffic and children's respiratory health. Environ Health Perspect. 2008; 116:1274–1279.

19. Melén E, Nyberg F, Lindgren CM, Berglind N, Zucchelli M, Nordling E, et al. Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. Environ Health Perspect. 2008; 116:1077–1084.

20. Hong SJ, Lee MS, Sohn MH, Shim JY, Han YS, Park KS, et al. Self-reported prevalence and risk factors of asthma among Korean adolescents: 5-year follow-up study, 1995-2000. Clin Exp Allergy. 2004; 34:1556–1562.

21. American Thoracic Society. Standardization of Spirometry, 1994 Update. Am J Respir Crit Care Med. 1995; 152:1107–1136.

22. Jörres RA, Nowak D, Kirsten D, Grönke L, Magnussen H. A short protocol for methacholine provocation testing adapted to the Rosenthal-Chai dosimeter technique. Chest. 1997; 111:866–869.

23. Oftedal B, Brunekreef B, Nystad W, Nafstad P. Residential outdoor air pollution and allergen sensitization in schoolchildren in Oslo, Norway. Clin Exp Allergy. 2007; 37:1632–1640.

24. Motta AC, Marliere M, Peltre G, Sterenberg PA, Lacroix G. Traffic-related air pollutants induce the release of allergen-containing cytoplasmic granules from grass pollen. Int Arch Allergy Immunol. 2006; 139:294–298.

25. Traidl-Hoffmann C, Kasche A, Menzel A, Jakob T, Thiel M, Ring J, et al. Impact of pollen on human health: more than allergen carriers? Int Arch Allergy Immunol. 2003; 131:1–13.

26. Ciencewicki J, Trivedi S, Kleeberger SR. Oxidants and the pathogenesis of lung diseases. J Allergy Clin Immunol. 2008; 122:456–468.

27. Diaz-Sanchez D, Proietti L, Polosa R. Diesel fumes and the rising prevalence of atopy: an urban legend? Curr Allergy Asthma Rep. 2003; 3:146–152.

28. Ryan PH, LeMasters G, Biagini J, Bernstein D, Grinshpun SA, Shukla R, et al. Is it traffic type, volume, or distance? Wheezing in infants living near truck and bus traffic. J Allergy Clin Immunol. 2005; 116:279–284.

29. Liu J, Ballaney M, Al-alem U, Quan C, Jin X, Perera F, et al. Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo. Toxicol Sci. 2008; 102:76–81.

30. Weijers EP, Khlystov AY, Kos GP, Erisman JW. Variability of particulate matter concentrations along roads and motorways determined by a moving measurement unit. Atmos Environ. 2004; 38:2993–3002.