Allergy Asthma Respir Dis.  2016 Jul;4(4):248-256. 10.4168/aard.2016.4.4.248.

Air pollution and childhood allergic disease

• Yoo Y

• KMID: 2346753
• DOI: http://doi.org/10.4168/aard.2016.4.4.248

Abstract

Epidemiological studies suggest that there is a strong relationship between air pollution and childhood allergic disease. This review will summarize the association between exposure to air pollutants and subsequent development of asthma, allergies, and sensitization. Air pollutants probably induce oxidative stress, epigenetic change, and altered microRNA expression in the airway and skin, leading to immune dysregulation. This review considers acute and chronic effects of air pollution on the development and aggravation of allergic disease; the adverse health effect of air pollution on susceptible population, particular time period, and coexposure to allergens; and potential mechanisms involving development of allergic disease by exposure to air pollutants.

Keyword

Air pollution; Allergy; Environment

MeSH Terms

Air Pollutants
Air Pollution*
Allergens
Asthma
Epidemiologic Studies
Epigenomics
Hypersensitivity
MicroRNAs
Oxidative Stress
Skin
Air Pollutants
Allergens
MicroRNAs

Figure

• 

  Fig. 1 Exposure to air pollutants in susceptible population can elicit epithlial barrier dysfunction, oxidative stress, epigenetic change and immune imbalance which subsequently increases allergic disease morbidity. PM, particulate matter; DEP, diesel exhaust particle; PAHs, polycyclic aromatic hydrocarbons; ETS, environmental tobacco smoke; HDM, house dust mite.

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