Exp Neurobiol.
2013 Mar;22(1):18-22. 10.5607/en.2013.22.1.18.
Memantine Reverses Social Withdrawal Induced by Ketamine in Rats
- Affiliations
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- 1Laboratorio de Neurofisiologia, Escuela De Ciencias Biomedicas y Tecnologicas Dr. Guillermo Mujica Sevilla, Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Venezuela. ezequiel.uribe@hotmail.com
- 2Hospital Dr. Rafael Gonzalez Plaza, Departamento de Neuropsiquiatria. INSALUD, Gobernacion del Estado Carabobo. Edo. Carabobo 2001, Venezuela.
- KMID: 2165437
- DOI: http://doi.org/10.5607/en.2013.22.1.18
Abstract
- The objective of this study was to determine the effect of memantine on schizophrenia-like symptoms in a ketamine-induced social withdrawal model in rats. We examined therapeutic effects of memantine, an NMDA antagonist, and haloperidol, a classic antipsychotic drug, on this behavioral model. Administration of memantine (10 or 15 mg.kg(-1)) significantly reduced ketamine-induced social withdrawal, and this effect was more effective than that of haloperidol (0.25 mg.kg(-1)) by restoring the social interaction between rats with no modification in general motor activity. These results suggest that memantine could have a therapeutic potential for schizophrenia.
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