- Comparison of Intraoperative Low-Dose Ketodex and Fentanyl Infusion for Postoperative Analgesia In Spine Surgery: A Prospective Randomized Double-Blind Study
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Thappa P, Singh N, Luthra A, Deshpande P, Chauhan R, Meena SC, Kumar V, Singla N
- KMID: 2547586
- Asian Spine J.
- 2023 Oct;17(5):894-903.
- doi: 10.31616/asj.2022.0439
Study Design: Prospective randomized double-blind study. Purpose: To assess the analgesic effects of the combination of a low-dose ketamine and dexmedetomidine (ketodex) infusion and compare it with that of fentanyl for... -
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- The Role of Glutamate Underlying Treatment-resistant Depression
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Kim J, Kim TE, Lee SH, Koo JW
- KMID: 2545804
- Clin Psychopharmacol Neurosci.
- 2023 Aug;21(3):429-446.
- doi: 10.9758/cpn.22.1034
The monoamine hypothesis has significantly improved our understanding of mood disorders and their treatment by linking monoaminergic abnormalities to the pathophysiology of mood disorders. Even 50 years after the monoamine... -
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- Refractory and super-refractory status epilepticus and evidence for the use of ketamine: a scope review
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Espinosa L, Gomez M, Zamora A, Molano-Franco D
- KMID: 2543386
- J Neurocrit Care.
- 2023 Jun;16(1):1-9.
- doi: 10.18700/jnc.230003
Status epilepticus (SE) is a neurological emergency with serious consequences for neuronal tissues, therefore, it is considered the most serious manifestation of epilepsy. The response to treatment, its evolution time... -
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- Ketamine-propofol (ketofol) in procedural sedation: a narrative review
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Choi EJ, Kim CH, Yoon JY, Kim EJ
- KMID: 2543043
- J Dent Anesth Pain Med.
- 2023 Jun;23(3):123-133.
- doi: 10.17245/jdapm.2023.23.3.123
Sedation methods for dental treatment are increasingly explored. Recently, ketofol, which is a combination of ketamine and propofol, has been increasingly used because the advantages and disadvantages of propofol and... -
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- Comparative evaluation of intranasal midazolam-ketamine, dexmedetomidine-ketamine, midazolam-fentanyl, and dexmedetomidine-fentanyl combinations for procedural sedation and analgesia in pediatric dental patients: a randomized controlled trial
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Agarwal A, Ansari AA, Nath R, Chak RK, Singh RK, Khanna R, Singh PR
- KMID: 2541477
- J Dent Anesth Pain Med.
- 2023 Apr;23(2):69-81.
- doi: 10.17245/jdapm.2023.23.2.69
Background: In order to assess the effectiveness of various analgesio-sedative combinations for pain relief and sedation in pediatric dental patients, a thorough evaluation of clinical studies and patient outcomes is... -
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- 4-F-PCP, a Novel PCP Analog Ameliorates the Depressive-Like Behavior of Chronic Social Defeat Stress Mice via NMDA Receptor Antagonism
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Ortiz DMD, Kim M, Lee HJ, Botanas CJ, Perez Custodio RJ, Sayson LV, Campomayor NB, Lee C, Lee YS, Cheong JH, Kim HJ
- KMID: 2539592
- Biomol Ther.
- 2023 Mar;31(2):227-239.
- doi: 10.4062/biomolther.2022.159
Major depressive disorder is a leading cause of disability in more than 280 million people worldwide. Monoamine-based antidepressants are currently used to treat depression, but delays in treatment effects and... -
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- Anti-N-methyl-D-aspartate Receptor Encephalitis in Illicit Substance Use
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Sung E, Kang IM, Kim H, Lee H, Park J
- KMID: 2539088
- J Korean Neurol Assoc.
- 2023 Feb;41(1):48-51.
- doi: 10.17340/jkna.2023.1.8
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuroinflammatory disease mediated by autoantibodies against the NMDAR, typically presenting with psychiatric symptoms, cognitive dysfunction, and motor dysfunction. These neuropsychiatric symptoms may be mimicked... -
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- Subdissociative-dose ketamine for sickle cell vaso-occlusive crisis: a narrative review for the emergency physician
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Bawany MH, Motov SM
- KMID: 2534209
- Clin Exp Emerg Med.
- 2022 Sep;9(3):169-175.
- doi: 10.15441/ceem.22.326
Vaso-occlusive crisis (VOC) in sickle cell disease can cause severe pain and requires a thoughtful approach to analgesia. Considering the heightened awareness of the harm associated with opioids, an exploration... -
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- Where is the Mechanistic Target of Rapamycin Signaling Pathway in Depression?
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Lee JA
- KMID: 2538385
- Mood Emot.
- 2022 Jul;20(2):23-30.
- doi: 10.35986/me.2022.20.2.23
Although the pathophysiology of depression has not been clearly elucidated yet, the mTOR (mechanistic target of rapamycin) signaling pathway has recently taken an increasingly important position in the pathophysiology of... -
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- Efficacy and safety of low dose oral ketamine for controlling pain and distress during intravenous cannulation in children: a double-blind, randomized, placebo-controlled trial
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Bagheri M, Soltani AE, Qorbani M, Sureda A, Faghihi T
- KMID: 2530986
- Korean J Pain.
- 2022 Jul;35(3):311-318.
- doi: 10.3344/kjp.2022.35.3.311
Background: Ketamine is widely used in infants and young children for procedural sedation and anesthesia. The aim of this study was to evaluate the efficacy and safety of low dose... -
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- Comparison of nebulized dexmedetomidine and ketamine for premedication in pediatric patients undergoing hernia repair surgery: a randomized comparative trial
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Singariya G, Malhotra N, Kamal M, Jaju R, Aggarwal S, Bihani P
- KMID: 2531693
- Anesth Pain Med.
- 2022 Apr;17(2):173-181.
- doi: 10.17085/apm.21081
Background: Allaying anxiety and providing calm children in the operating room is a challenging task for anesthesiologists. This study was designed to compare the use of nebulized dexmedetomidine and ketamine... -
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- Subanesthetic intravenous ketamine vs. caudal bupivacaine for postoperative analgesia in children undergoing infra-umbilical surgeries: a non-inferiority randomized, single-blind controlled trial
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Sahoo AK, Misra S, Behera BK, Srinivasan A, Jena SS, Mohanty MK
- KMID: 2530002
- Korean J Anesthesiol.
- 2022 Apr;75(2):178-184.
- doi: 10.4097/kja.21373
Background: Subanesthetic intravenous (IV) ketamine acts as an analgesic and has opioid-sparing effects, particularly for acute postoperative pain; however, its effectiveness in children is understudied. The primary aim... -
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- Evaluation of the Effect of Continuous Infusion of Dexmedetomidine or a Subanesthetic Dose Ketamine on Transcranial Electrical Motor Evoked Potentials in Adult Patients Undergoing Elective Spine Surgery under Total Intravenous Anesthesia: A Randomized Controlled Exploratory Study
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Andleeb R, Agrawal S, Gupta P
- KMID: 2529528
- Asian Spine J.
- 2022 Apr;16(2):221-230.
- doi: 10.31616/asj.2021.0015
Study Design: Prospective, randomized, placebo-controlled, double-blind exploratory study. Purpose: To compare effects of dexmedetomidine or a subanesthetic dose of ketamine on the amplitude and latency of transcranial electrically generated motor evoked... -
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- The effects of ketamine on pain control in stage IV cancer patients receiving palliative care
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Kim S, Kang J, Choi J, Kong E
- KMID: 2527693
- Kosin Med J.
- 2022 Mar;37(1):37-45.
- doi: 10.7180/kmj.21.003
Background: We evaluated the effects of intravenous ketamine on cancer pain in stage IV cancer patients receiving palliative care. Methods: In total, 253 stage IV cancer patients with cancer pain hospitalized... -
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- Comparison of bolus administration effects of lidocaine on preventing tourniquet-induced hypertension in patients undergoing general anesthesia: a randomized controlled trial
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Kim JW, Lee AR, Park ES, Yun MS, Ryu SW, Kim UG, Kang DH, Kim JD
- KMID: 2526525
- Anesth Pain Med.
- 2022 Jan;17(1):35-43.
- doi: 10.17085/apm.21055
Background: This study assessed the effect of a single bolus administration of lidocaine on the prevention of tourniquet-induced hypertension (TIH) and compared the effect of lidocaine to that of ketamine... -
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- Efficacy of ketamine in the treatment of migraines and other unspecified primary headache disorders compared to placebo and other interventions: a systematic review
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Chah N, Jones M, Milord S, Al-Eryani K, Enciso R
- KMID: 2520783
- J Dent Anesth Pain Med.
- 2021 Oct;21(5):413-429.
- doi: 10.17245/jdapm.2021.21.5.413
Background: Migraine headaches are the second leading cause of disability worldwide and are responsible for significant morbidity, reduction in the quality of life, and loss of productivity on a global... -
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- Pediatric Sedation in the Emergency Department: Trends from a Nationwide Population-based Study in Korea, 2007–2018
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Lee JY, Choi SJ, Park JS, Lee JS, Ryu JM, Yum MS
- KMID: 2519353
- J Korean Med Sci.
- 2021 Aug;36(33):e213.
- doi: 10.3346/jkms.2021.36.e213
Background: Pediatric sedation in the emergency department (ED) is widely performed in Korea; thus exploring the trends of its use is necessary. This study aimed to investigate the characteristics of... -
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- Procedural Sedation for Pediatric Upper Gastrointestinal Endoscopy in Korea
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Lee YM, Kang B, Kim YB, Kim HJ, Lee KJ, Lee Y, Choi SY, Lee EH, Yi DY, Jang HJ, Choi YJ, Hong SJ, Kim JY, Kang Y, Kim SC
- KMID: 2516048
- J Korean Med Sci.
- 2021 May;36(20):e136.
- doi: 10.3346/jkms.2021.36.e136
Background: Sedative upper endoscopy is similar in pediatrics and adults, but it is characteristically more likely to lead to respiratory failure. Although recommended guidelines for pediatric procedural sedation are available... -
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- Ketamine-induced generalized convulsive seizure during procedural sedation
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Kim JH, Lee CK, Yu SH, Min BD, Chung CE, Kim DC
- KMID: 2515413
- Arch Craniofac Surg.
- 2021 Apr;22(2):119-121.
- doi: 10.7181/acfs.2021.00094
Ketamine is used widely in emergency departments for a variety of purposes, including procedural sedation for facial laceration in pediatric patients. The major benefits are its rapid onset of effects,... -
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- Comeback of ketamine: resurfacing facts and dispelling myths
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Kumar A, Kohli A
- KMID: 2514493
- Korean J Anesthesiol.
- 2021 Apr;74(2):103-114.
- doi: 10.4097/kja.20663
Initially known as CI-581, ketamine was first synthesized in 1962 as a replacement from phencyclidine. It has since been used as an anesthetic and analgesic. In addition, it has bronchodilating,... -
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