J Korean Pain Soc.
1995 Apr;8(1):18-24.
Effects of Ketamine on the Causalgiform Pain Produced by the Tight Ligation of L5, L6 Spinal Nerves in the Rat
- Affiliations
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- 1Department of Anesthesiology, College of Medicine, Chungnam National University, Taecheon, Korea.
- 2Kim Tae Heon Clinic, Cheongju, Korea.
Abstract
- We produced the causalgiform pain by the tight ligation of L5 and L6 spinal nerves in the adult rats. To evalute the effect of ketamine noncompetitive NMDA (N-methyl-D aspartate) antagoinst on the causalgiform pain, we tested the changes of; withdrawal sensitivity to the innocuous mechanical stimulation of Von Frey hair 2.35 g (mechanical allodyniag withdrawal frequency to the cold stimulation of acetone (cold allodynia); and total withdrawal time (second) to the cold (4 degrees C) plate stimulation (cold hyperalgesia) after the administration of I mg, 3 mg, 10 mg/kg ketamine. The results were as follows: 1) Cold hyperalgesia was significantly reduced (p<0.05) by 1 mg, 3 mg, 10 mg/kg ketamine. 2) Cold allodynia and mechanical allodynia was significantly reduced (p<0.05) by 10 mg/kg keiamine. Above results suggest a therapeutic utility of ketamine in treatment of causalgia especially, cold hyperalgesia.
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