Korean J Anesthesiol.  2004 Dec;47(6):S14-S17. 10.4097/kjae.2004.47.6.S14.

Steroid on Hyperalgesia in Nerve Ligation Induced Neuropathic Pain Rat Model

• Kim TK
• Kim YS
• Kim MG

• KMID: 2032620
• DOI: http://doi.org/10.4097/kjae.2004.47.6.S14

Abstract

BACKGROUND: Neuropathic pain is resistant to conventional treatments, and may seriously affect the quality of life. Insufficient has been done on drug combination for the treatment of neuropathic pain. So we undertook to determine the effect of ketamine and steroid on mechanical hyperalgesia in rats with spinal nerve ligation.
METHODS
Rats were administerend L5 and L6 spinal nerve ligation to cause mechanical hyperalgesia. Control group (n = 6) were administered normal saline 5 ml intraperitoneally, the ketamine group (n = 6) ketamine 1mg/kg, and the steroid group (n = 6) ketamine 1 mg/kg and methylprednisolone 10 mg/kg. Mechanical hyperalgesia was assessed using a von Frey filament before injection, and then 15, 30, 60, 120, and 180 min after injection.
RESULTS
Ketamine 1 mg/kg significantly attenuated mechanical hyperalgesia for 60 min. The combination of ketamine 1 mg/kg and methylprednisolone 10 mg/kg also significantly attenuated mechanical hyperalgesia. But the combination group did not exert a superior attenuating effect than ketamine alone.
CONCLUSIONS
The combination of ketamine and metylprednisolone did not exert a superior antinociceptive effect than ketamine alone in rats with spinal nerve ligation.

Keyword

combination; ketamine; methylprednisolone; neuropathic pain

MeSH Terms

Animals
Hyperalgesia*
Ketamine
Ligation*
Methylprednisolone
Models, Animal*
Neuralgia*
Quality of Life
Rats*
Spinal Nerves
Ketamine
Methylprednisolone