J Korean Diabetes.  2016 Mar;17(1):51-59. 10.4093/jkd.2016.17.1.51.

Retrospective Observational Dose-Titration Study of Subjects with Type 2 Diabetes Mellitus with Inadequate Glycemic Control on 15 mg of Pioglitazone

• Ha SY
• Jung HW
• Choi YJ
• Lee HK
• Choi JW
• Choi JH
• Noh JH
• Hong JW
• Kim DJ

• KMID: 2161132
• DOI: http://doi.org/10.4093/jkd.2016.17.1.51

Abstract

BACKGROUND
The 30 mg pioglitazone tablet was recently introduced in Korea; no study has yet compared its glucose-lowering or weight gain effects to the 15 mg tablet in Korean patients with type 2 diabetes mellitus (T2DM).
METHODS
The electronic medical records of 45 patients with T2DM with glycated hemoglobin (HbA1c) levels > 7.0%, despite taking 15 mg/day pioglitazone and a stable dose of other diabetes drugs for 3 months, were retrospectively reviewed.
RESULTS
After dose up-titration, HbA1c levels decreased at 3- and 6-month follow-ups compared with baseline (8.5% at baseline vs. 8.2% at 3 months vs. 7.9% at 6 months; baseline vs. 3 months, P = 0.106; baseline vs. 6 months, P = 0.005; 3 months vs. 6 months, P = 0.096). In the subgroup analysis of 36 patients taking pioglitazone, sulfonylurea, and metformin, HbA1c levels also decreased at 3- and 6-month follow-ups compared with baseline (8.5 % vs. 8.2 % vs. 7.9%; baseline vs. 3 months, P = 0.289; baseline vs. 6 months, P = 0.014; 3 months vs. 6 months, P = 0.232). There was no significant body weight change (70.8 kg vs. 70.7 kg vs. 71.0 kg).
CONCLUSION
Up-titrating from 15 mg to 30 mg of pioglitazone in patients with inadequate glycemic control (HbA1c > 9%) who were also taking sulfonylurea and metformin showed additive glucose-lowering effects without significant weight gain in Korean patients with T2DM.

Keyword

Body weight; Diabetes mellitus; Glycated hemoglobin; Thiazolidinediones

MeSH Terms

Body Weight
Body Weight Changes
Diabetes Mellitus
Diabetes Mellitus, Type 2*
Electronic Health Records
Follow-Up Studies
Hemoglobin A, Glycosylated
Humans
Korea
Metformin
Retrospective Studies*
Thiazolidinediones
Weight Gain
Metformin
Thiazolidinediones

Figure

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  Fig. 1. Effect of dose-up titration of pioglitazone. (A) Effect of dose-up titration of pioglitazone on glycated hemoglobin (HbA1c; n = 45). (B) Effect of dose-up titration of pioglitazone on fasting plasma glucose (FPG; n = 45). (C) Effect of dose-up titration of pioglitazone on HbA1c in sulfonylurea (SU) + metformin (MET) subgroup (n = 36). (D) Effect of dose-up titration of pioglitazone on HbA1c in maximal dose of SU + MET subgroup (n = 27).

Reference

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