Osong Public Health Res Perspect.  2018 Aug;9(4):167-174. 10.24171/j.phrp.2018.9.4.05.

Factors that Correlate with Poor Glycemic Control in Type 2 Diabetes Mellitus Patients with Complications

Affiliations
  • 1Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, India. rajanmsv123@gmail.com
  • 2Nutrition Health Research Center, Student Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
  • 3Department of Microbiology, Islamic Azad University, Lahijan Branch, Rasht, Iran.

Abstract


OBJECTIVES
Inadequate glycemic control amongst patients with Type 2 diabetes mellitus (T2DM) indicates a major public health problem and a significant risk factor for the progression and complications caused by diabetes. Glycemic control is the main therapeutic objective for the prevention of organ damage and other complications arising from diabetes.
METHODS
This was a retrospective observational study of T2DM patients with complications, who were aged 40 years and older. The study was conducted retrospectively on medical records (in-patient and out-patient) obtained from a South Indian teaching hospital, Manipal, India. The patients included in the study had fasting blood sugar, postprandial blood sugar and HbA1c measured at least twice during follow-ups the previous year. Patients' HbA1c levels were categorized into good control ≤7% (≤53mmol/mol), and poor control >7% (>53mmol/mol), and patients' characteristics were analyzed.
RESULTS
A total of 657 patients were included in the study. The mean age was 59.67 (SD = 9.617) years, with 152 (23.1%) females and 505 (76.9%) males, and 514 (78.2%) patients had poor glycemic control. Most of the patients were on insulin mono-therapy [n = 271 (42.1%)], about a third of the patients were on combination therapy that included an oral hypoglycemic agent and insulin [n = 236 (36.6%)]. Patients with a history of more than 10 years of diabetes [n = 293 (44.6%)], had a family history of diabetes [n = 256 (39%)] and obesity [n = 95 (14.5%)], all had poor glycemic control.
CONCLUSION
This present study indicated a significant association of gender (female), age, high-density lipoprotein level, duration of diabetes and type of medication, with poor glycemic control in T2DM patients that had secondary medical complications.

Keyword

diabetes mellitus; glycemic; diabetes complications; glycosylated hemoglobin A1c

MeSH Terms

Blood Glucose
Diabetes Complications
Diabetes Mellitus
Diabetes Mellitus, Type 2*
Fasting
Female
Follow-Up Studies
Hospitals, Teaching
Humans
India
Insulin
Lipoproteins
Male
Medical Records
Obesity
Observational Study
Public Health
Retrospective Studies
Risk Factors
Blood Glucose
Insulin
Lipoproteins
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