Ann Clin Microbiol.  2016 Mar;19(1):28-31. 10.5145/ACM.2016.19.1.28.

Two Cases of Medical Device-Related Corynebacterium striatum Infection: A Meningitis and A Sepsis

• Park S
• Chung HS
• Seo EK
• Mun YC
• Lee M

• KMID: 2160083
• DOI: http://doi.org/10.5145/ACM.2016.19.1.28

Abstract

Corynebacterium striatum is a commonly isolated contaminant in the clinical microbiology. However, it can be an opportunistic pathogen in immunocompromised and even immunocompetent hosts. The increasing prevalence of C. striatum infection has been associated with immunosuppression and prosthetic devices. We report a case of meningitis with cerebrospinal fluid drainage and a case of catheter-related bloodstream infection caused by C. striatum. The isolates were identified as nondiphtherial Corynebacterium species by VITEK 2 (bioMérieux, France) anaerobe and Corynebacterium card. The final identification by 16S rRNA gene sequencing analysis was C. striatum with 99.7% identity and 99.6% identity with C. striatum ATCC 6940, respectively. Both strains were sensitive to vancomycin and gentamicin, but multidrug-resistant to ciprofloxacin, penicillin, erythromycin and imipenem.

Keyword

Bloodstream infection; Corynebacterium striatum; Meningitis; 16S rRNA gene sequencing

MeSH Terms

Cerebrospinal Fluid
Ciprofloxacin
Corynebacterium*
Drainage
Erythromycin
Genes, rRNA
Gentamicins
Imipenem
Immunosuppression
Meningitis*
Penicillins
Prevalence
Sepsis*
Vancomycin
Ciprofloxacin
Erythromycin
Gentamicins
Imipenem
Penicillins
Vancomycin

Reference

References

1. Lee PP, Ferguson DA Jr, Sarubbi FA. Corynebacterium striatum: an underappreciated community and nosocomial pathogen. J Infect. 2005; 50:338–43.

2. Bowstead TT and Santiago SM. Pleuropulmonary infection due to Corynebacterium striatum. Br J Dis Chest. 1980; 74:198–200.

3. Boltin D, Katzir M, Bugoslavsky V, Yalashvili I, Brosh-Nissimov T, Fried M, et al. Corynebacterium striatum–a classic pathogen eluding diagnosis. Eur J Intern Med. 2009; 20:e49–52.

4. Renom F, Gomila M, Garau M, Gallegos MD, Guerrero D, Lalucat J, et al. Respiratory infection by Corynebacterium striatum: epidemiological and clinical determinants. New Microbes New Infect. 2014; 2:106–14.

5. Reece RM, Cunha CB, Rich JD. Corynebacterium minutissimum vascular graft infection: case report and review of 281 cases of prosthetic device-related Corynebacterium infection. Scand J Infect Dis. 2014; 46:609–16.

6. Schuurman T, de Boer RF, Kooistra-Smid AM, van Zwet AA. Prospective study of use of PCR amplification and sequencing of 16S ribosomal DNA from cerebrospinal fluid for diagnosis of bacterial meningitis in a clinical setting. J Clin Microbiol. 2004; 42:734–40.

7. Kim OS, Cho YJ, Lee K, Yoon SH, Kim M, Na H, et al. Introducing EzTaxon-e: a prokaryotic 16S rRNA gene sequence database with phylotypes that represent uncultured species. Int J Syst Evol Microbiol. 2012; 62:716–21.

8. Funke G, von Graevenitz A, Clarridge JE 3rd, Bernard KA. Clinical microbiology of coryneform bacteria. Clin Microbiol Rev. 1997; 10:125–59.

9. Choi HS, Kim JS, Jung ES, Kim AJ, Jung H, Park YS, et al. A case of postoperative intra-abdominal infection caused by Corynebacterium striatum. Korean J Med. 2012; 82:516–9.

10. Yoo G, Kim J, Uh Y, Lee HG, Hwang GY, Yoon KJ. Multidrug-resistant Corynebacterium striatum bacteremia: first case in Korea. Ann Lab Med. 2015; 35:472–3.

11. Yang HS, Kim YJ, Cho SY, Shin E, Lee HJ. Central venous catheter-related bloodstream infection by Corynebacterium striatum identified by 16S rRNA and rpoB gene sequencing. Ann Lab Med. 2015; 35:548–50.

12. Khamis A, Raoult D, La Scola B. rpoB gene sequencing for identification of Corynebacterium species. J Clin Microbiol. 2004; 42:3925–31.

13. Bernard K. The genus corynebacterium and other medically relevant coryneform-like bacteria. J Clin Microbiol. 2012; 50:3152–8.

14. Otsuka Y, Ohkusu K, Kawamura Y, Baba S, Ezaki T, Kimura S. Emergence of multidrug-resistant Corynebacterium striatum as a nosocomial pathogen in long-term hospitalized patients with underlying diseases. Diagn Microbiol Infect Dis. 2006; 54:109–14.

15. Olender A. Mechanisms of antibiotic resistance in Corynebacterium spp. causing infections in people. In:. Pana M, editor. ed.Antibiotic resistant bacteria – A continuous challenge in the new millennium. 1st ed. InTech: 2012. p. 387–402.