Immune Netw.  2005 Jun;5(2):55-67. 10.4110/in.2005.5.2.55.

Cancer Vaccines

• Son EW
• In SW
• Pyo S

• KMID: 2150599
• DOI: http://doi.org/10.4110/in.2005.5.2.55

Abstract

Cancer vaccine is an active immunotherapy to stimulate the immune system to mount a response against the tumor specific antigen. Working as a stimulant to the body's own immune system, cancer vaccines help the body recognize and destroy targeted cancers and may help to shrink advanced tumors. Research is currently underway to develop therapeutic cancer vaccines. It is also possible to develop prophylactic vaccines in the future. The whole cell approach to eradicate cancer has used whole cancer cells to make vaccine. In an early stage of this approach, whole cell lysate or a mixture of immunoadjuvant and inactivated cancer cells has been used. Improved vaccines are being developed that utilize cytokines or costimulatory molecules to mount an attack against cancer cells. In case of melanoma, these vaccines are expected to have a therapeutic effect of vaccine. Furthermore, it is attempting to treat stomach cancer, colorectal cancer, pancreatic cancer, and prostate cancer. Other vaccines are being developing that are peptide vaccine, recombinant vaccine and dendritic cell vaccine. Out of them, reintroduction of antigen-specific dendritic cells into patient and DNA vaccine are mostly being conducted. Currently, research and development efforts are underway to develop therapeutic cancer vaccine such as DNA vaccine for the treatment of multiple forms of cancers.

Keyword

Cancer vaccine; DNA; dendritic cell; immunotherapy

MeSH Terms

Cancer Vaccines*
Colorectal Neoplasms
Cytokines
Dendritic Cells
DNA
Humans
Immune System
Immunotherapy
Immunotherapy, Active
Melanoma
Pancreatic Neoplasms
Prostatic Neoplasms
Stomach Neoplasms
Vaccines
Cancer Vaccines
Cytokines
DNA
Vaccines