Immune Netw.  2001 Apr;1(1):32-35. 10.4110/in.2001.1.1.32.

The healing effect of rhGM - CSF on uninfected wounds

• Han SK
• Kim BS
• Kim AR
• Seo JH
• Choi CW
• Shin SW
• Kim YH
• Kim WK
• Kim JS

• KMID: 2150554
• DOI: http://doi.org/10.4110/in.2001.1.1.32

Abstract

BACKGROUND: rhGM-CSF has been shown to enhance the migration and proliferation of endothelial cells and to promote keratinocyte growth. This study was tried to evaluate the effect of rhGM-CSF dressing on the uninfected wounds.
METHODS
Thirty Sprague-dawley white mice(250-300g) were selected in this study . The number of wound with the diameter of 5 mm, was 3 in left and 3 in right at the symmetric sites, respectively . The site of rhGM-CSF dressing was decided by a randomization. rhGM-CSF(Leucogen (r)) was diluted in the distilled water(5 micro gram/mL). The experimental wound group was dressed by l mL of distilled water mixed with rhGM-CSF and control wound group was dressed by l mL of distilled water. The dressing was done, every 24 hours. The criteria of comparison were the duration of wound healing duration, histologic findings and the bacterial culture of wound sites.
RESULTS
The duration of wound healing was 10.3+/-1.7 days in experimental group and 10.2+/-2.8 days in control group, without significant difference. There was no specific difference of histologic findings between both groups. The pathogen was not found, at all.
CONCLUSION
It seems to be that rhGM-CSF has no prominent effect on the uninfected wound healing in the mice without immune suppression.

Keyword

rhGM - CSF; uninfected wound healing

MeSH Terms

Animals
Bandages
Endothelial Cells
Keratinocytes
Mice
Random Allocation
Rats, Sprague-Dawley
Water
Wound Healing
Wounds and Injuries*
Water