Korean J Pediatr Hematol Oncol.  1999 Apr;6(1):20-30.

Efficacy of Recombinant Human Granulocyte Colony Stimulating Factor (rhG-CSF) and Recombinant Human Granulocyte Macrophage Colony Stimulating Factor (rhGM-CSF) in Neutropenic Children with Malignancies

• Lee GH
• Choi KH
• Hah JO

Abstract

PURPOSE: Current intensive anticancer therapy may cause myelosuppression with an increased risk of severe infections. As a result, the administration of chemotherapy in cancer patients might be delayed often. Hemopoietic growth factors, which are responsible for the differentiation and functional regulation of granulocytes and monocytes, have been cloned and are available as rhG-CSF and rhGM-CSF. The aim of this study was to compare the efficacy and side effects of rhG-CSF and rhGM-CSF in children with cancer who received chemotherapy.
METHODS
The study included 55 children ranging in age from 2 to 18 years who received chemotherapy for cancer and had absolute neutrophil count (ANC) under 500/muL. The growth-factors were administered subcutaneously starting in doses of 5~10 mug/ kg/day. The ANC was determined by complete blood counts starting on the first day of administration and every other day thereafter until the ANC rose above 1,000/muL.
RESULTS
There was no significant difference in the mean days for increase of the mean ANC value >500/muL (5.0+/-2.9 vs 5.7+/-4.2 days) and >1,000/muL (5.9+/-3.2 vs 6.4+/-4.8 days) after rhG-CSF and rhGM-CSF respectively. Side effects of rhG-CSF and rhGM-CSF were fever, myalgia, bone pain, elevation of ALT and rGT and abdominal pain in order and there was no difference between two growth factors. Also the numbers of transfusion of packed RBCs (0.7+/-0.8 vs 0.7+/-0.8) and platelets (0.8+/-1.0 vs 0.6+/-0.9) were not different after the two growth factors.
CONCLUSION
It seems to be that rhG-CSF and rhGM-CSF are comparable in clinical effects and side effects when used for granulocytopenia in children with cancer.

Keyword

rhG-CSF; rhGM-CSF; Neutropenia

MeSH Terms

Abdominal Pain
Agranulocytosis
Blood Cell Count
Child*
Clone Cells
Colony-Stimulating Factors*
Drug Therapy
Fever
Granulocyte-Macrophage Colony-Stimulating Factor*
Granulocytes*
Humans*
Intercellular Signaling Peptides and Proteins
Monocytes
Myalgia
Neutropenia
Neutrophils
Colony-Stimulating Factors
Granulocyte-Macrophage Colony-Stimulating Factor
Intercellular Signaling Peptides and Proteins