Korean J Hematol.  2000 Nov;35(3-4):258-262.

Evaluation of Peripheral White Blood Cell Count or Monocyte Count to Guide Timing of Mobilized Stem Cell Collection in Patients with Breast Cancer

• Min YJ
• Suh C
• Kim HJ
• Kim S
• Kim EK
• Jang G
• Park J
• Park KU
• Lee K
• Kim TW
• Kim SB
• Kim SW
• Lee JS
• Park JH
• Kim WK
• Kim SH

Abstract

BACKGROUND: The optimal timing of peripheral blood stem cell (PBSC) collection is essential to successful procurement of sufficient PBSC for engraftment. The purpose of this study was to evaluate the peripheral blood parameters that may predict the apheretic yield of circulating stem cells in patients with breast cancer.
METHODS
We did a retrospective review of 29 patients with breast cancer (14 : high risk, 15 : metastatic disease) who underwent mobilizing therapy from Dec. 1992 to Jan. 1999. Immediately prior to 119 consecutive PBSC collection procedures, the PB white blood cell (WBC) and monocyte were determined and correlated with stem cell parameters namely, CD34+ cell and mononuclear cell content.
RESULTS
The median of 0.57x106CD34+cells/kg patient body weight (range, 0-9.39) were collected per harvest. The WBC on the day of apheresis showed only weak correlation with the mononuclear cells collected (r=0.26). In contrast, the WBC count and monocyte count in PB did not correlated with CD34+ cells harvested
CONCLUSION
WBC and monocyte count are not appropriate parameters to identify the exact timing for apheresis and predict the amount of peripheral blood stem cells collected in patients with breast cancer.

Keyword

Peripheral blood stem cells; Apheresis; White cell count; Monocyte count; Breast cancer

MeSH Terms

Blood Component Removal
Body Weight
Breast Neoplasms*
Breast*
Humans
Leukocyte Count*
Leukocytes*
Monocytes
Retrospective Studies
Stem Cells*