J Korean Soc Endocrinol.  1998 Jun;13(2):240-246.

A Case of SIADH Related to Drug-indeced Generalized Maculopapular Rash

• Yoo SJ
• Lee KW
• Son HY
• Kang SK
• Cha BY
• Song HJ
• Choi JY
• Park JN
• Huh D

Abstract

Syndrome of inappropriate antidiutetic hormone(SIADH) secretion is the most common cause of hyponatremia in clinical medicine. Before diagnosis of the SIADH is made, other causes for a decreased diluting capacity and nonosmotic stimuli for AVP release need to be rule out. Disorders associated with SIADH can be divided into 4 major etiologic groups: malignancies, pulmonary diseases, central nervous disorders, and drugs. A 45-year-old woman was admitted due to maculopapular skin eruption and fever after taking medications for fever and myalgia. Generalized tonic clonic seizure was developed nine days later, and laboratory results showed marked hyponatremia. During the evaluation, treatment, and subsequent follow-up, the diagnosis of SIADH was confirmed, but the definitive cause was obscure. With fluid restriction, sodium replacement and demeclocycline therapy, she recovered completely 6 months later. We suggest that the SIADH might be related to drug-induced generalized maculopapular rash via menmgitis-like reaction in CSF as one of systemic adverse side effects to drugs rather than direct effect of related drugs.

MeSH Terms

Clinical Medicine
Demeclocycline
Diagnosis
Exanthema*
Female
Fever
Follow-Up Studies
Humans
Hyponatremia
Inappropriate ADH Syndrome*
Lung Diseases
Middle Aged
Myalgia
Seizures
Skin
Sodium
Demeclocycline
Sodium