Korean J Pathol.  1999 Dec;33(12):1120-1130.

Relationship among the Expression of Cyclin D1, p21, and p53 Protein, and Prognosis in Non-Small Cell Lung Carcinomas

• Yang SW
• Cho SH
• Yang WI
• Jung WH
• Ahn CM
• Lee DY

Abstract

Recently, cell cycle regulators have been suggested as new prognostic factors of the lung cancer. In this study, we evaluated the expression of cyclin D1, p21, and p53 using the X2-test, with regard to the stage of the patients, histologic type, and histologic differentiation in the 135 cases of non-small cell lung carcinomas (NSCLC). To evaluate the confounding effects among cyclin D1, p21, and p53 on X2-test analysis, we used the Mantel-Haenzel test. The NSCLC in this study included 82 cases of squamous cell carcinoma and 53 cases of adenocarcinoma. Each nuclear staining of cyclin D1, p21, and p53 was observed in 65 cases (48.1%), in 54 cases (40.0%), and in 81 cases (60.0%) of NSCLCs, respectively. Only p53 expression was significantly associated with the stage (stage I, II, IIIa) (p<0.05) and squamous cell carcinoma (p<0.05). On the other hand, cyclin D1 expression was significantly associated with the histologic differentiation. The confounding effects among cyclin D1, p21, and p53 revealed that only p21 expression changed the relationship between p53 and stage. In this regard, further study is needed.

Keyword

Non-small cell lung carcinoma; Stage; Cyclin D1; p21; p53

MeSH Terms

Adenocarcinoma
Carcinoma, Squamous Cell
Cell Cycle
Cyclin D1*
Cyclins*
Hand
Humans
Lung Neoplasms
Lung*
Prognosis*
Cyclin D1
Cyclins