- Expression of phosphorylated p21-activated kinase 4 is associated with aggressive histologic characteristics and poor prognosis in patients with surgically treated renal cell carcinoma
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- KMID: 2516919
- Investig Clin Urol.
- 2021 Jul;62(4):399-407.
- doi: 10.4111/icu.20200399
Purpose: P21-activated kinase 4 (PAK4), a serine/threonine kinase that regulates a number of fundamental cellular processes, has been suggested as a prognostic factor for various human tumors. The aim of... -
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- Overexpression of p21 Has Inhibitory Effect on Human Hematopoiesis by Blocking Generation of CD43＋ Cells via Cell-Cycle Regulation
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Zeng J, Zhang H, Liu Y, Sun W, Yi D, Zhu L, Zhang Y, Pan X, Chen Y, Zhou Y, Bian G, Lai M, Zhou Q, Liu J, Chen B, Ma F
- KMID: 2504333
- Int J Stem Cells.
- 2020 Jul;13(2):202-211.
- doi: 10.15283/ijsc20033
Background and Objectives: p21, an important member of the Cip/Kip family, is involved in inhibitory effects of RUNX1b overexpression during the early stage of human hematopoiesis. Methods and Results: We established... -
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- The role of p21/CIP1/WAF1 (p21) in the negative regulation of the growth hormone/growth hormone receptor and epidermal growth factor/epidermal growth factor receptor pathways, in growth hormone transduction defect
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Kostopoulou E, Rojas Gil , Spiliotis
- KMID: 2432278
- Ann Pediatr Endocrinol Metab.
- 2018 Dec;23(4):204-209.
- doi: 10.6065/apem.2018.23.4.204
PURPOSE: Growth hormone transduction defect (GHTD) is characterized by severe short stature, impaired STAT3 (signal transducer and activator of transcription-3) phosphorylation and overexpression of the cytokine inducible SH2 containing protein... -
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- Agmatine Ameliorates High Glucose-Induced Neuronal Cell Senescence by Regulating the p21 and p53 Signaling
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Song J, Lee B, Kang S, Oh Y, Kim E, Kim CH, Song HT, Lee JE
- KMID: 2165575
- Exp Neurobiol.
- 2016 Feb;25(1):24-32.
- doi: 10.5607/en.2016.25.1.24
Neuronal senescence caused by diabetic neuropathy is considered a common complication of diabetes mellitus. Neuronal senescence leads to the secretion of pro-inflammatory cytokines, the production of reactive oxygen species, and... -
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- Small Double-Stranded RNA Mediates the Anti-Cancer Effects of p21(WAF1/ClP1) Transcriptional Activation in a Human Glioma Cell Line
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Dong Z, Dang Y, Chen Y
- KMID: 2386458
- Yonsei Med J.
- 2014 Mar;55(2):324-330.
PURPOSE: This study was conducted to investigate the small double-stranded RNA (dsRNA) mediated anti-tumor effects of p21(WAF1/ClP1) (p21) transcriptional activation in vitro in the human glioma SHG-44 cell line. MATERIALS AND... -
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- Prolonged expression of senescence markers in mice exposed to gamma-irradiation
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Seol MA, Jung U, Eom HS, Kim SH, Park HR, Jo SK
- KMID: 2391990
- J Vet Sci.
- 2012 Dec;13(4):331-338.
Although ionizing radiation is known to induce cellular senescence in vitro and in vivo, its long-term in vivo effects are not well defined. In this study, we examined the prolonged... -
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- p21-Activated Kinases (PAKs) as a Therapeutic Target
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Koo BS
- KMID: 2277281
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2011 Dec;54(12):813-818.
- doi: 10.3342/kjorl-hns.2011.54.12.813
p21-activated kinases (PAKs) are a family of serine/threonine protein kinases comprised of six isoform (PAK1-6), all of which are direct targets of the small GTPases Rac and Cdc42. PAKs have... -
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- Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor via mitogen-activated protein kinase
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Jung GA, Shin BS, Jang YS, Sohn JB, Woo SR, Kim JE, Choi G, Lee KM, Min BH, Lee KH, Park GH
- KMID: 1123367
- Exp Mol Med.
- 2011 Oct;43(10):550-560.
- doi: 10.3858/emm.2011.43.10.061
Protein arginine methylation is important for a variety of cellular processes including transcriptional regulation, mRNA splicing, DNA repair, nuclear/cytoplasmic shuttling and various signal transduction pathways. However, the role of arginine... -
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- Chlorpromazine activates p21(Waf1/Cip1) gene transcription via early growth response-1 (Egr-1) in C6 glioma cells
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Shin SY, Kim CG, Kim SH, Kim YS, Lim Y, Lee YH
- KMID: 946639
- Exp Mol Med.
- 2010 May;42(5):395-405.
- doi: 10.3858/emm.2010.42.5.041
2-Chloro-10-[3(-dimethylamino)propyl]phenothiazinemonohydrochloride (chlorpromazine) is a phenothiazine derivative used clinically to control psychotic disorders. It also exhibits an anticancer activity. Treatment with chlorpromazine (CPZ) results in cell-cycle arrest at the G2/M phase... -
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- JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis
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Moon DO, Kim MO, Kang CH, Lee JD, Choi YH, Kim GY
- KMID: 756210
- Exp Mol Med.
- 2009 Sep;41(9):665-677.
- doi: 10.3858/emm.2009.41.9.073
The JNK inhibitor SP600125 strongly inhibits cell proliferation in many human cancer cells by blocking cell-cycle progression and inducing apoptosis. Despite extensive study, the mechanism by which SP600125 inhibits mitosis-related... -
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- The orphan nuclear receptor SHP inhibits apoptosis during the monocytic differentiation by inducing p21WAF1
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Kim K, Choi YH, Kim HH, Cheong J
- KMID: 756235
- Exp Mol Med.
- 2009 Jun;41(6):429-439.
- doi: 10.3858/emm.2009.41.6.048
Small heterodimer partner (SHP) is an atypical member of nuclear receptor superfamily that lacks a DNA-binding domain. In previous study, we showed that SHP, c-jun, p65 of NF-kappaB subunits, and... -
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- Transient downregulation of protein O-N-acetylglucosaminylation by treatment of high-dose nicotinamide in human cells
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Lee HI, Cho HJ, Han JA, Jang SY, Wang KM, Kang HT, Hwang ES
- KMID: 1052947
- Exp Mol Med.
- 2008 Apr;40(2):246-253.
- doi: 10.3858/emm.2008.40.2.246
Nicotinamide at millimolar concentrations affects cell survival in various conditions, and is being utilized therapeutically in many human diseases. However, the effect of an acute treatment of nicotinamide at such... -
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- P21 and p53 expression in patients with epithelial ovarian carcinoma
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Kim YJ, Nam DG, Lee JK, Cho SH, Kim KT
- KMID: 2128121
- Korean J Obstet Gynecol.
- 2007 Dec;50(12):1695-1705.
OBJECTIVE: Mutations in p53 are the most common genetic alterations in human malignancies. Expression of its protein product has been linked to decreased survival rate in ovarian carcinoma. P53 is... -
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- p53, p21 and bcl-2 Protein Expressions and the Clinical Significance in Papillary Thyroid Carcinoma
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Jung TS, Kim KS, Oh YL, Jung JH, Lee EY, Jung HS, Min YK, Lee MS, Lee MK, Kim KW, Chung JH
- KMID: 1523089
- J Korean Endocr Soc.
- 2007 Apr;22(2):98-104.
- doi: 10.3803/jkes.2007.22.2.98
BACKGROUND: There have been some investigations concerning the role of p53, p21 and bcl-2 protein expressions for the tumorigenesis of thyroid cancer. It had been debated that these protein expressions... -
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- Trichostatin A-mediated upregulation of p21
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Yi T, Baek JH, Kim HJ, Choi MH, Seo SB, Ryoo HM, Kim GS, Woo KM
- KMID: 1094662
- Exp Mol Med.
- 2007 Apr;39(2):213-221.
Histone deacetylase inhibitors (HDIs), a new class of anti-cancer agents, have been reported to suppress formation of osteoclast precursors and their fusion into multinucleated cells. However, little is known about... -
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- Mechanism of Amelioration of Cisplatin Nephrotoxicity by Procaine Treatment in Mice
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Ahn DW, Kim SR, Ha DH, Kim SH
- KMID: 1937597
- Korean J Anesthesiol.
- 2007 Mar;52(3):318-327.
- doi: 10.4097/kjae.2007.52.3.318
BACKGROUND: Procaine binds to DNA and reduces cisplatin nephrotoxicity, but the mechanism is poorly understood. We explored whether procaine amelioration of cisplatin nephrotoxicity was related to down-and/or up-regulation of inflammatory... -
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- Expression of Mutant p53 Protein, p21(waf1/cip1) and Cyclin D1 in Dysplasia and Adenocarcinoma of Stomach
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Yun KJ, Kim HS, Jo HJ, Choi SC
- KMID: 2304817
- Korean J Gastrointest Endosc.
- 2007 Jan;34(1):9-13.
BACKGROUND/AIMS: Gastric carcinoma is a major cause of morbidity and mortality in Korea. It evolves through dysplasia to an invasive adenocarcinoma. The carcinogenesis of dysplasia and adenocarcinoma in the stomach... -
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- The Effects of p21 on Bladder Cancers
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Jung W, Cho IC, Ha YS, Jo SH, Park MS, Lee YS, Yoon SJ, Kim WJ
- KMID: 2294271
- Korean J Urol.
- 2006 Nov;47(11):1149-1154.
- doi: 10.4111/kju.2006.47.11.1149
Purpose: p21 protein is an inhibitor of cyclin-dependent kinases, which may be able to arrest the cell cycle at the G1 phase by inhibiting DNA replication through the interaction with... -
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- Genistein Induces G2/M Cell Cycle Arrest and Apoptosis in Rat Neuroblastoma B35 Cells; Involvement of p21(waf1/cip1), Bax and Bcl-2
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Ismail IA, Kang KS, Kim JW, Sohn YK
- KMID: 1640304
- Korean J Pathol.
- 2006 Oct;40(5):339-347.
BACKGROUND: The effect of genistein on different types of cells has been investigated. However, its effect on the nervous system is still unclear. The aim of the present work is... -
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- Low-dose radiation response of the p21(WAF1/CIP1) gene promoter transduced by adeno-associated virus vector
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Nenoi M, Daino K, Ichimura S, Takahash S, Akuta T
- KMID: 1098090
- Exp Mol Med.
- 2006 Oct;38(5):553-564.
In cancer gene therapy, restriction of antitumor transgene expression in a radiation field by use of ionizing radiation-inducible promoters is one of the promising approaches for tumor-specific gene delivery. Although... -
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