Korean J Pathol.  2013 Oct;47(5):411-417.

Clinicopathological Analysis of Hepatocellular Adenoma According to New Bordeaux Classification: Report of Eight Korean Cases

• Kim H
• Jang JJ
• Kim DS
• Yeom BW
• Won NH

Abstract

BACKGROUND
Hepatocellular adenoma (HCA) is a rare benign tumor of the liver. A subtype classification of HCA (hepatocyte nuclear factor 1alpha [HNF1alpha]-mutated, beta-catenin-mutated HCA, inflammatory HCA, and unclassified HCA) has recently been established based on a single institutional review of a HCA series by the Bordeaux group.
METHODS
We used histologic and immunohistochemical parameters to classify and evaluate eight cases from our institution. We evaluated the new classification method and analyzed correlations between our results and those of other reports.
RESULTS
Seven of our eight cases showed histologic and immunohistochemical results consistent with previous reports. However, one case showed overlapping histologic features, as previously described by the Bordeaux group. Four cases showed glutamine synthetase immunohistochemical staining inconsistent with their classification, indicating that glutamine synthetase staining may not be diagnostic for beta-catenin-mutated HCA. HNF1alpha-mutated HCA may be indicated by the absence of liver fatty acid binding protein expression. Detection of amyloid A may indicate inflammatory HCA. HCA with no mutation in the HNF1alpha or beta-catenin genes and no inflammatory protein expression is categorized as unclassified HCA.
CONCLUSIONS
Although the new classification is now generally accepted, validation through follow-up studies is necessary.

Keyword

Adenoma, liver cell; Subtype; Hepatocyte nuclear factor 1-alpha; Beta catenin; Serum amyloid A protein

MeSH Terms

Adenoma, Liver Cell*
Amyloid
beta Catenin
Fatty Acid-Binding Proteins
Glutamate-Ammonia Ligase
Hepatocyte Nuclear Factor 1-alpha
Liver
Serum Amyloid A Protein
Amyloid
Fatty Acid-Binding Proteins
Glutamate-Ammonia Ligase
Hepatocyte Nuclear Factor 1-alpha
Serum Amyloid A Protein
beta Catenin