J Korean Soc Radiol.  2019 Jan;80(1):153-156. 10.3348/jksr.2019.80.1.153.

Metastasis of Hepatocellular Carcinoma to Pituitary Adenoma: A Case Report

• Hong YS
• Cho YS
• Kim CG
• Lee MJ

• KMID: 2442476
• DOI: http://doi.org/10.3348/jksr.2019.80.1.153

Abstract

Metastasis to the pituitary gland is unusual, and metastasis to pituitary adenoma is extremely rare. We report here on a case of hepatocellular carcinoma metastasizing to a pituitary adenoma with MRI findings.

MeSH Terms

Adenoma
Carcinoma, Hepatocellular*
Magnetic Resonance Imaging
Neoplasm Metastasis*
Pituitary Gland
Pituitary Neoplasms*

Figure

• 

  Fig. 1. A 72-year-old man with HCC metastasis to pituitary adenoma presenting with oculomotor nerve palsy. A, B. Initial sella MRI (A, coronal T2-weighted; B, coronal contrast-enhanced T1-weighted image 30 second after administration of gadolinium) demonstrate a tumor (2.6 × 1.1 cm) located in pituitary fossa and left cavernous sinus. The tumor is revealed as slight hyper-intensity compared with gray matter on T2-weighted image and relatively homogeneous enhancement after administration of gadolinium. C, D. Two years later, sella MRI (C, coronal T2-weighted; D, coronal contrast-enhanced T1-weighted image 30 second after administration of gadolinium) show increase in size of pituitary tumor (2.8 × 1.3 cm). On T2-weighted image (C), distinct hypointense nodular area is seen within pre-existing sellar tumor showing strong enhancement after admis-tration of gadolinium on T1-weighted image (D). E, F. Histological tumor specimens (× 200). (E) Hematoxylin and eosin staining of the pituitary tumor shows metastatic HCC (#) to pituitary adenoma (∗). (F) Hepatocyte specific antigen immunohistochemical result shows reactive in metastatic HCC (#). HCC = hepatocellular carcinoma

Reference

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