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Current status and analysis of brain death organ donor’s management through introduction of electronic notification system potential brain death donor

Jeon SY, Jeong NY, Jo SM, Song SH, Jung HJ, Jang JJ, Choi YJ, Woo EJ

Background: According to the Act on Transplantation of Organs, etc., the head of a medical institution that has treated a potential brain death donor is required to notify the head...
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Alteration of MRP2 expression and the graft outcome after liver transplantation

Yi NJ, Kim J, Choi Y, Kim H, Lee KB, Jang JJ, Lee JY, Lee JM, Han JK, Lee KW, Suh KS

PURPOSE: Multidrug resistance-associated protein (MRP) 2 is a glutathione conjugate in the canalicular membrane of hepatocytes. Early graft damage after liver transplantation (LT) can result in alteration of MRP2 expression....
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Prognosis of Hepatocellular Carcinoma after Liver Transplantation: Comparative Analysis with Partial Hepatectomy

Lee K, Lee KB, Yi NJ, Suh KS, Jang JJ

BACKGROUND: Liver transplantation (LT) is the treatment of choice for hepatocellular carcinoma (HCC). The aim of this study was to investigate the recurrence rate of HCC after LT and prognostic...
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C3H/He Mice as an Incompatible Cholangiocarcinoma Model by Clonorchis sinensis, Dicyclanil and N-Nitrosodimethylamine

Uddin MH, Li S, Jin Y, Choi MH, Jang JJ, Hong ST

Clonorchis sinensis is a Group-I bio-carcinogen, associated with cholangiocarcinoma (CCA). The hamster is the only experimental model of C. sinensis-mediated CCA, but we oblige another animal model. The present study...
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Nuclear Expression of Hepatitis B Virus X Protein Is Associated with Recurrence of Early-Stage Hepatocellular Carcinomas: Role of Viral Protein in Tumor Recurrence

Jin J, Jung HY, Lee KH, Yi NJ, Suh KS, Jang JJ, Lee KB

BACKGROUND: Hepatitis B virus (HBV) plays well-known roles in tumorigenesis of hepatocellular carcinoma (HCC) in infected patients. However, HBV-associated protein status in tumor tissues and the relevance to tumor behavior...
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A Case Of Huge Brunner's Gland Adenoma With Acute Bleeding Treated By Endoscopic Resection

Park PK, Chung WC, Lee KY, Lee SH, Jang JJ, Suh S

Brunner's gland adenoma is a rare benign small bowel neoplasm and it represents 10% of small bowel benign tumor. Most of adenoma manifest as polypoidal, multiple and size does not...
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A novel prognostic factor for hepatocellular carcinoma: protein disulfide isomerase

Yu SJ, Won JK, Ryu HS, Choi WM, Cho H, Cho EJ, Lee JH, Kim YJ, Suh KS, Jang JJ, Kim CY, Lee HS, Yoon JH, Cho KH

BACKGROUND/AIMS: Protein disulfide isomerase (PDI) has been implicated in the survival and progression of some cancer cells, by compensating for endoplasmic reticulum stress by upregulating the protein-folding capacity. However, its...
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Clinicopathological Analysis of Hepatocellular Adenoma According to New Bordeaux Classification: Report of Eight Korean Cases

Kim H, Jang JJ, Kim DS, Yeom BW, Won NH

  • KMID: 2141001
  • Korean J Pathol.
  • 2013 Oct;47(5):411-417.
BACKGROUND: Hepatocellular adenoma (HCA) is a rare benign tumor of the liver. A subtype classification of HCA (hepatocyte nuclear factor 1alpha [HNF1alpha]-mutated, beta-catenin-mutated HCA, inflammatory HCA, and unclassified HCA) has...
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ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma

Jang JY, Lee YS, Jeon YK, Lee K, Jang JJ, Kim CW

  • KMID: 2154222
  • Exp Mol Med.
  • 2013 Jan;45(1):e3.
MicroRNAs (miRNAs) participate in diverse biological functions and carcinogenesis by inhibiting specific gene expression. We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by using the short hairpin...
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The Histologic Cut-off Point for Adjacent and Remote Non-neoplastic Liver Parenchyma of Hepatocellular Carcinoma in Chronic Hepatitis B Patients

Jung HY, Kim SH, Jing J, Gwak JM, Han CJ, Jang JJ, Lee KB

BACKGROUND: The molecular profile of peritumoral non-neoplastic liver parenchyma (PNLP) has recently been suggested as predictive factor of early and late recurrence of hepatocellular carcinoma (HCC). However, there is no...
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Pharmacological Unmasking Microarray Approach-Based Discovery of Novel DNA Methylation Markers for Hepatocellular Carcinoma

Jung N, Won JK, Kim BH, Suh KS, Jang JJ, Kang GH

DNA methylation is one of the main epigenetic mechanisms and hypermethylation of CpG islands at tumor suppressor genes switches off these genes. To find novel DNA methylation markers in hepatocellular...
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Chemotherapy-Associated Hepatopathy in Korean Colorectal Cancer Liver Metastasis Patients: Oxaliplatin-Based Chemotherapy and Sinusoidal Injury

Nam SJ, Cho JY, Lee HS, Choe G, Jang JJ, Yoon YS, Han HS, Kim H

BACKGROUND: Although chemotherapy-related hepatic injury has been reported in colorectal cancer liver metastasis (CRLM) patients, the morphologic changes caused by chemotherapeutic agents and the effect of chemotherapy on postoperative outcome...
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Clinicopathologic Features of Q Fever Patients with Acute Hepatitis

Lee M, Jang JJ, Kim YS, Lee SO, Choi SH, Kim SH, Yu E

BACKGROUND: Q fever caused by Coxiella burnetii presents with diverse clinical and pathological features including subclinical or cholestatic hepatitis. However, the pathological features of liver biopsies from patients with Q...
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Expression of the Transmembrane Glycoprotein CD44s Is Potentially an Independent Predictor of Recurrence in Hepatocellular Carcinoma

Ryu HS, Park SH, Lee KB, Shin E, Jang JJ

  • KMID: 2135094
  • Gut Liver.
  • 2011 Jun;5(2):204-209.
BACKGROUND/AIMS: Cluster differentiation 44 standard isoform (CD44s) is a transmembrane glycoprotein. CD44s is a known prognostic factor in various cancers, due to its involvement in tumor cell growth, invasion and...
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Validation of P2/MS and Other Noninvasive Fibrosis Scoring Systems in the Korean Population with Nonalcoholic Fatty Liver Disease

Yu SJ, Kim D, Lee JH, Chung GE, Yim JY, Park MJ, Kim YJ, Yoon JH, Jang JJ, Lee HS

BACKGROUND/AIMS: P2/MS is a noninvasive marker for detecting hepatic fibrosis in patients with viral hepatitis. However, the applicability of P2/MS in patients with nonalcoholic fatty liver disease (NAFLD) has not...
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Identification of Novel Methylation Markers in Hepatocellular Carcinoma using a Methylation Array

Shin SH, Kim BH, Jang JJ, Suh KS, Kang GH

Promoter CpG island hypermethylation has become recognized as an important mechanism for inactivating tumor suppressor genes or tumor-related genes in human cancers of various tissues. Gene inactivation in association with...
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Differential Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Thioacetamide-Induced Chronic Liver Injury

Park SY, Shin HW, Lee KB, Lee MJ, Jang JJ

Hepatic fibrogenesis, a complex process that involves a marked accumulation of extracellular matrix components, activation of cells capable of producing matrix materials, cytokine release, and tissue remodeling, is regulated by...
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Anti-hepatofibrogenic Effect of Turnip Water Extract on Thioacetamide-induced Liver Fibrosis

Li L, Park DH, Li YC, Park SK, Lee YL, Choi HM, Han DS, Yang HJ, Lee EH, Jang HK, Kim YJ, Jang JJ, Lee MJ

Liver fibrosis is a chronic liver disease and lots of people in Korea are suffered. There are many efforts to find candidates to suppress liver fibrogenesis and several chemical-induced model...
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Hepatocellular Carcinoma with Immature T-Cell (T-lymphoblastic) Proliferation

Eun S, Jeon YK, Jang JJ

Indolent T-lymphoblastic proliferation has been rarely reported in the upper aerodigestive tract. The lymphoid cells associated with this condition have the morphological and phenotypical features of immature thymocytes. However, their...
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Validation of P2/MS for reflecting hepatic fibrosis in patients with hepatocellular carcinoma

Yu SJ, Lee JH, Chung GE, Lee CH, Cho EJ, Jang ES, Kwak MS, Kim YJ, Yoon JH, Jang JJ, Lee HS

BACKGROUND/AIMS: P2/MS is known as a simple, accurate, and noninvasive marker for determination of the degree of hepatic fibrosis in patients with viral hepatitis. We aimed to validate P2/MS in...
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