Korean J Perinatol.  2002 Dec;13(4):399-405.

The Expression of Death Domain Receptor-3, Caspase-10, Insulin-Like Growth Factor Binding Protein-3 in the Placentas of Preeclampsia

• Paik WY
• Choi WJ
• Lee SA
• Lee JH
• Choi WS

Abstract

OBJECTIVE
To determine that preeclampsia is associated with differential expression of death domain receptor-3(DDR-3), caspase-10, and insulin-like growth factor binding protein-3(IGFBP-3).
METHODS
Placenta were collected from 10 preeclampsias and from 15 normal pregnancies and the samples were immediately frozen and stored at -70degrees C. Total mRNA was extracted from placental tissue and then analysis of the expressions of DDR-3, caspase-10, and IGFBP-3 were performed by quantitative RT-PCR.
RESULTS
Quantitative RT-PCR analysis demonstrated significantly increased DDR-3 and caspase-10 expression levels and significantly decreased IGFBP-3 expression level in the placenta of preeclampsia compared with normal pregnancy.
CONCLUSION
Placental apoptosis is associated with DDR-3, caspase-10, and IGFBP-3. These results may be one of possible mechanisms in the placental apoptosis of preeclampsia.

Keyword

DDR-3; Caspase-10; IGFBP-3; Placental apoptosis; Preeclampsia

MeSH Terms

Apoptosis
Caspase 10*
Insulin-Like Growth Factor Binding Protein 3
Placenta*
Pre-Eclampsia*
Pregnancy
RNA, Messenger
Caspase 10
Insulin-Like Growth Factor Binding Protein 3
RNA, Messenger