Endocrinol Metab.  2017 Mar;32(1):11-17. 10.3803/EnM.2017.32.1.11.

Recent Insights into Insulin-Like Growth Factor Binding Protein 2 Transcriptional Regulation

• Shin M
• Kang HS
• Park JH
• Bae JH
• Song DK
• Im SS

• KMID: 2413280
• DOI: http://doi.org/10.3803/EnM.2017.32.1.11

Abstract

Insulin-like growth factor binding proteins (IGFBPs) are major regulators of insulin-like growth factor bioavailability and activity in metabolic signaling. Seven IGFBP family isoforms have been identified. Recent studies have shown that IGFBPs play a pivotal role in metabolic signaling and disease, including the pathogenesis of obesity, diabetes, and cancer. Although many studies have documented the various roles played by IGFBPs, transcriptional regulation of IGFBPs is not well understood. In this review, we focus on the regulatory mechanisms of IGFBP gene expression, and we summarize the findings of transcription factor activity in the IGFBP promoter region.

Keyword

Insulin-like growth factor binding protein 2; Transcriptional regulation; Metabolic diseases; Liver

MeSH Terms

Biological Availability
Gene Expression
Humans
Insulin-Like Growth Factor Binding Protein 2*
Insulin-Like Growth Factor Binding Proteins
Liver
Metabolic Diseases
Obesity
Promoter Regions, Genetic
Protein Isoforms
Transcription Factors
Insulin-Like Growth Factor Binding Protein 2
Insulin-Like Growth Factor Binding Proteins
Protein Isoforms
Transcription Factors