J Rhinol.  2006 May;13(1):5-9.

Roles of IL-8 in the Pathogenesis of Chronic Rhinosinusitis

• Rhyoo C

Abstract

Epithelial hyperplasia and mucosal infiltration of leukocytes are common features of chronic rhino sinusitis. The epithelium can produce chemo attractant cytokines that may contribute to leukocyte infiltration in rhino sinusitis. IL-8 is a chemokine that can be produced in large amounts by epithelial cells in response to a variety of stimuli including proinflammatory cytokines, bacteria, fungi, and respiratory viruses. This chemokine is not only a potent chemoattractant for, and activator of, neutrophils, but it is also chemotactic for some subsets of T lymphocytes. Moreover, IL-8 has been reported to serve as a chemoattractant for eosinophils from subjects with allergic disease. Thus it is reasonable to hypothesize that this chemokine could contribute to the pathogenesis of chronic rhino sinusitis. This article reviews the role of IL-8 in the pathogenesis of chronic rhino sinusitis.

Keyword

Interleukin-8; Chronic rhinosinusitis

MeSH Terms

Bacteria
Cytokines
Eosinophils
Epithelial Cells
Epithelium
Fungi
Hyperplasia
Interleukin-8*
Leukocytes
Neutrophils
Sinusitis
T-Lymphocytes
Cytokines
Interleukin-8