Immune Netw.  2018 Apr;18(2):e6. 10.4110/in.2018.18.e6.

Pathogenesis of Recalcitrant Chronic Rhinosinusitis: The Emerging Role of Innate Immune Cells

• Kong IG
• Kim DW

• KMID: 2410157
• DOI: http://doi.org/10.4110/in.2018.18.e6

Abstract

Chronic rhinosinusitis (CRS) is a major part of the recalcitrant inflammatory diseases of the upper airway that needs enormous socioeconomic burden. T helper (Th) 2 type immune responses recruiting eosinophils were the most well-known immune players in CRS pathogenesis especially in western countries. By the piling up of a vast amount of researches to elucidate the pathogenic mechanism of CRS recently, heterogeneous inflammatory processes were found to be related to the phenotypes of CRS. Recently more cells other than T cells were in the focus of CRS pathogenesis, such as the epithelial cell, macrophage, innate lymphoid cells, and neutrophils. Here, we reviewed the recent research focusing on the innate immune cells related to CRS pathogenesis.

Keyword

Chronic rhinosinusitis; Nasal polyps; Recalcitrant chronic rhinosinusitis; Pathogenesis; Innate immune cell

MeSH Terms

Eosinophils
Epithelial Cells
Lymphocytes
Macrophages
Nasal Polyps
Neutrophils
Phenotype
T-Lymphocytes