J Rhinol.
2000 Nov;7(2):149-153.
Inhibition of Murine Allergic Response by Monoclonal Interleukin-4 Receptor Antibody
- Affiliations
-
- 1Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul, Korea. chulhee@snu.ac.kr
- 2Department of Otolaryngology, Sanggye Paik Hospital, Inje University, Seoul, Korea.
Abstract
-
BACKGROUND AND OBJECTIVES: Several strategies were used to control the IgE production by interfering the functional activities of IL-4. However, most of them revealed limited effects to reduction of allergic response. This study was aimed to investigate the effects of interleukin-4 receptor (IL-4R) antibody on allergic response in animal model of allergic rhinitis.
MATERIALS AND METHODS
Male BALB/C mice were sensitized with intraperitoneal injection of ovalbumin (OVA). IL-4R antibody was injected intravenously before intranasal challenge of OVA with ultrasonic nebulizer. Allergic symptoms, a number of eosinophils in nasal mucosa and serum level of OVA-specific IgE were evaluated.
RESULTS
In IL-4R antibody treated mice, allergic symptom score were decreased (53.5%) than in control mice. The number of eosinophils in nasal mucosa were also reduced (47.4%). However, serum level of OVA-specific IgE were not obviously reduced (14.3%).
CONCLUSION
These results suggested that IL-4R antibody has a potential effect for the treatment of allergic rhinitis in vivo.
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Inhibition of Allergic Response by Intranasal Selective NF-κB Decoy Oligodeoxynucleotides in a Murine Model of Allergic Rhinitis
- Updated Pathophysiology of rheumatoid arthritis
- IL-4/IL-13 Cytokine and Receptor in Asthma
- New drugs for Rheumatoid arthritis
- Targeted Molecular Therapy in a Murine Model of Oral Squamous Cell Carcinoma with an Epidermal Growth Factor Receptor Inhibitor
