J Korean Neurol Assoc.  2015 Nov;33(4):297-305. 10.17340/jkna.2015.4.9.

High Frequency Repetitive Transcranial Magnetic Stimulation for Freezing of Gait and Nonmotor Symptoms in Parkinson's Disease

• Oh E
• Park S
• Lim J
• Lee AY
• Bok SK
• Song HJ

• KMID: 2129318
• DOI: http://doi.org/10.17340/jkna.2015.4.9

Abstract

BACKGROUND
To investigate the effect of high frequency repetitive transcranial magnetic stimulation (rTMS) on motor symptoms especially freezing of gait (FoG), and nonmotor symptoms in Parkinson disease (PD).
METHODS
In this randomized, double-blind, sham-controlled study, fifteen PD patients were enrolled. For 10 days, 5 Hz, both motor cortices and dorsolateral prefrontal cortex (DLPFC) were stimulated. The motor symptoms and FoG were evaluated by the Unified Parkinson's Disease Rating Scale (UPDRS) part III, FoG questionnaire (FoG-Q), variable parameters of FoG, and kinematic gait analysis. Nonmotor symptoms were evaluated by the Korean version of non-Motor Symptoms Scale (K-NMSS), 39-item Parkinson disease questionnaire (K-PDQ39), Mini-Mental Status examination (K-MMSE), Montreal Cognitive Assessment (K-MoCA), and Frontal assessment battery (FAB).
RESULTS
Finally, 12 patients (real:8, sham:4) data were analyzed. FoG-Q and UPDRS part III were improved (p=0.002, 0.022) and variable parameters of FoG was improved after 10 days stimulation in real treatment group. In addition, their effects maintained until 6 weeks from the baseline. In nonmotor symptoms, K-NMSS and K-PDQ 39 were improved until 6 weeks in real treatment group (p=0.002, 0.002), however no changes were shown in cognitive function test.
CONCLUSIONS
The high frequency rTMS was effective for FoG, in addition to motor and a few nonmotor symptoms in PD.

Keyword

Repetitive transcranial magnetic stimulation (rTMS); Freezing of gait (FoG); Parkinson's disease

MeSH Terms

Freezing*
Gait*
Humans
Parkinson Disease*
Prefrontal Cortex
Transcranial Magnetic Stimulation*
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