Clin Psychopharmacol Neurosci.  2019 Aug;17(3):443-445. 10.9758/cpn.2019.17.3.443.

New Onset Obsessive Compulsive Disorder Following High Frequency Repetitive Transcranial Magnetic Stimulation over Left Dorsolateral Prefrontal Cortex for Treatment of Negative Symptoms in a Patient with Schizophrenia

• Garg H
• Kumar S
• Singh S
• Kumar N
• Verma R

• KMID: 2457409
• DOI: http://doi.org/10.9758/cpn.2019.17.3.443

Abstract

Obsessive-compulsive symptoms and/or obsessive-compulsive disorders (OCD) are frequently comorbid with schizophrenia, though the exact clinical and etiological relationship between them is poorly understood. Here we describe a case that, to the best of our knowledge, is the first report of new-onset OCD in a patient who was receiving high-frequency repetitive transcranial magnetic stimulation over left dorsolateral pre-frontal cortex as an adjuvant therapy for negative symptoms of schizophrenia. Thisreport supports our understanding of OCD as a brain disorder involving hyper-activity of pre-frontal cortex and cortico-striatal-thalamo-cortical circuit dysfunction.

Keyword

Obsessive-compulsive disorder; Negative symptoms; Schizophrenia; Transcranial magnetic stimulation

MeSH Terms

Brain Diseases
Humans
Obsessive-Compulsive Disorder*
Prefrontal Cortex*
Schizophrenia*
Transcranial Magnetic Stimulation*