J Korean Ophthalmol Soc.
2001 Jun;42(6):893-897.
Effect of Latanoprost on the Cultured Human Uveal Melanocytes
- Affiliations
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- 1Department of Ophthalmology, Catholic University of Daegu, Daegu, Korea.
Abstract
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PURPOSE: To investigate the effect of latanoprost on the melanogenesis and endogenous PG release.
METHODS
Primarily cultured uveal human melanocytes were exposed to 0.1 micrometer, 1 micrometer, and 10 micrometer of PhXA85 and also co-exposured with 1 micrometer of indomethacine or hydrocortisone, the melanin content of each melanocyte was measured with spectrophotometer after 1 week.
RESULTS
After 1 week, the melanin content of each melanocyte was increased with 1 micrometer, 10 micrometer of PhXA85(p<0.05). After co-exposure with indomethacine or hydrocortisone, the amount of increased melanin content was less than that of PhXA85 alone and statistically significant with 10 micrometer of PhXA85(p<0.05).
CONCLUSIONS
These results show that PhXA85 stimulates melanogenesis of cultured human uveal mela-nocytes and also suggests the possibility of exogenous PGF2 alpha-induced release of endogenous prostaglandin.
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