J Korean Ophthalmol Soc.
1988 Oct;29(5):901-907.
5-Fluorouracil in a Collagen Sponge and Glaucoma Filtering Surgery
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- 1Depatrment of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
Abstract
- A histologic study was performed if fibroblast proliferation could be inhibited and filtering bleb longevity could be enhanced in rabbits by delivery of 5-fluorouracil(0.5 mg) in a collagen sponge implant. Results showed that fibroblast proliferation was inhibited and bleb longevity was prolonged when compared to controls. And it is theorized that if an antitumor agents can be delivered in small and sustained amounts after filtering agents can be delivered in small and sustained amounts after filtering surgery, this may enhance bleb longevity and unnecessary drug toxicity.
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