J Korean Ophthalmol Soc.  1993 Oct;34(10):1044-1049.

The Effect of 5-FU(5-fluorouracil) in the Filtering Surgery

• Lee JH
• Yoon HS
• Rho SH

Abstract

An antimetabolite, 5-fluorouracil(5-FU) has a property of inhibiting fibroblast proliferahon and is known to increase success rate of glaucoma filtering surgery in patients at risk by preventing postoperative scarring of a filtering bleb. Thirteen eyes of 13 patients with uncontrolled glaucoma at high risk for failures of standard filteration underwent trabeculectomy with post-operative 5-FU subconjunctival injections. The mean follow-up time was 7.3 months. The intraocular pressure was controlled in 77% of the over-all study patients after 1 month, 69% after 2 months and 54% after 6months, respectively. In patients with neovascular glaucoma, the intraocular pressure was controlled in 80% of the patients after 1 month and 60% after 2 months and 40% after 6 months. A corneal epithelial defect was the most common complicatio. No other severe complications were observed.

Keyword

5-Fluorouracil; risky glaucoma; trabeculectomy

MeSH Terms

Blister
Cicatrix
Fibroblasts
Filtering Surgery*
Fluorouracil
Follow-Up Studies
Glaucoma
Glaucoma, Neovascular
Humans
Intraocular Pressure
Trabeculectomy
Fluorouracil