Arch Plast Surg.
2014 May;41(3):241-247. 10.5999/aps.2014.41.3.241.
Effects of the Diabetic Condition on Grafted Fat Survival: An Experimental Study Using Streptozotocin-Induced Diabetic Rats
- Affiliations
-
- 1Department of Plastic Surgery, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Korea.
- 2Department of Plastic and Reconstructive Surgery, Gachon University Gil Medical Center, Incheon, Korea.
- 3Department of Plastic and Reconstructive Surgery, Ewha Womans University Hospital, Ewha Womans University School of Medicine, Seoul, Korea. srps@ewha.ac.kr
- KMID: 2120869
- DOI: http://doi.org/10.5999/aps.2014.41.3.241
Abstract
- BACKGROUND
Autologous fat grafts have been widely used for cosmetic purposes and for soft tissue contour reconstruction. Because diabetes mellitus is one of the major chronic diseases in nearly every country, the requirement for fat grafts in diabetes patients is expected to increase continuously. However, the circulation complications of diabetes are serious and have been shown to involve microvascular problems, impairing ischemia-driven neovascularization in particular. After injection, revascularization is vital to the survival of the grafted fat. In this study, the authors attempted to determine whether the diabetic condition inhibits the survival of injected fat due to impaired neovascularization.
METHODS
The rat scalp was used for testing fat graft survival. Forty-four seven-week-old male Sprague-Dawley rats were allocated to a diabetic group or a control group. 1.0 mL of processed fat was injected subcutaneously into the scalp of each rat. The effect of diabetes was evaluated by calculating the volume and the weight of the grafted fat and by histologically analyzing the fat sections.
RESULTS
The surviving fat graft volume and weight were considerably smaller in the diabetic group than in the control group (P<0.05), and histological evaluations showed less vascularity, and more cysts, vacuoles, and fibrosis in the diabetic group (P<0.05). Cellular integrity and inflammation were not considerably different in the two groups.
CONCLUSIONS
As the final outcome, we found that the presence of diabetes might impair the survival and the quality of fat grafts, as evidenced by lower fat graft weights and volumes and poor histologic graft quality.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Proliferation of Cultured Vascular Smooth Muscle Cells(VSMCs) Obtained from Aortas of Insulin Dependent Diabetic Rats
- Protective Effect of Melatonin on Neuropathy in Streptozotocin-Induced Diabetic Rats
- Ultrastructural Changes of The Retinal Capillary Basement Membrane in The Streptozotocin-Induced Diabetic Rats
- The Effects of Nerve Growth Factor on Satellite Cell of the Dorsal Rott Ganglia in Streptozotocin-induced Diabetic Rats
- Effects of Polygonatum odoratum on In vivo Insulin Activity in Streptozotocin-Induced Diabetic Rats
