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The Role of Advanced Glycation End Products in Diabetic Vascular Complications

Rhee SY, Kim YS

In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs,...
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Factors Influencing Intention to Receive Examination of Diabetes Complications

Hsieh YL, Lee FH, Chen CL, Chang MF, Han PH

PURPOSE: The purpose of this study was to understand the situation of diabetes patients receiving examinations for diabetes complications and to explore the factors influencing their intention to receive examinations...
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Validation of Sinhala Version of Cardiff Wound Impact Schedule in Patients with Diabetic Leg and Foot Ulcers

Sriyani KA, Gunawardena N, Wasalathanthri S, Hettiarachchi P

PURPOSE: To validate the Cardiff Wound Impact Schedule (CWIS) to assess the health-related quality of life (HRQoL) of Sri Lankan patients with diabetic leg and foot ulcers. METHODS: English version of...
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Risk Factors for the Rupture of Bifurcation Intracranial Aneurysms Using CT Angiography

Wang GX, Zhang D, Wang ZP, Yang LQ, Zhang L, Wen L

PURPOSE: To investigate the clinical and morphological characteristics in relation to risk of bifurcation intracranial aneurysm rupture. MATERIALS AND METHODS: Data from 202 consecutive patients with 219 bifurcation aneurysms (129 ruptured...
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High glucose and palmitate increases bone morphogenic protein 4 expression in human endothelial cells

Hong OK, Yoo SJ, Son JW, Kim MK, Baek KH, Song KH, Cha BY, Jo H, Kwon HS

Here, we investigated whether hyperglycemia and/or free fatty acids (palmitate, PAL) aff ect the expression level of bone morphogenic protein 4 (BMP4), a proatherogenic marker, in endothelial cells and the...
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Relationship of Vascular Factors on Electrophysiologic Severity of Diabetic Neuropathy

Hwang JW, Pyun SB, Kwon HK

OBJECTIVE: To investigate the impact of vascular factors on the electrophysiologic severity of diabetic neuropathy (DPN). METHODS: Total 530 patients with type 2 diabetes were enrolled retrospectively. We rated severity of...
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Role of Bilirubin in Diabetic Vascular Complications: Can Bilirubin Predict More than Just Liver Disease?

Moon JS

No abstract available.
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Combination pharmacotherapy in lipid management

Lee SH

Latest guidelines on lipid management recommend statins as the first-line therapy. Because limited evidence is available on cardiovascular outcomes with varying statin-nonstatin combinations, recommendation levels for these regimens have been...
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Effect of Antiplatelets in Diabetic Peripheral Vasculopathy: Comparison by Ankle-Brachial Index and Peak Wave Velocity

Park SJ

PURPOSE: The purpose of this study is to confirm the effect of antiplatelet drugs in diabetic peripheral vasculopathy in diabetic foot patients. MATERIALS AND METHODS: We designed a retrospective study in...
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Effects of the Diabetic Condition on Grafted Fat Survival: An Experimental Study Using Streptozotocin-Induced Diabetic Rats

Jung JA, Kim YW, Cheon YW, Kang SR

BACKGROUND: Autologous fat grafts have been widely used for cosmetic purposes and for soft tissue contour reconstruction. Because diabetes mellitus is one of the major chronic diseases in nearly every...
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Association between Cardiac Autonomic Neuropathy, Diabetic Retinopathy and Carotid Atherosclerosis in Patients with Type 2 Diabetes

Jung CH, Baek AR, Kim KJ, Kim BY, Kim CH, Kang SK, Mok JO

BACKGROUND: It is not clear whether microangiopathies are associated with subclinical atherosclerosis in type 2 diabetes mellitus (T2DM). We investigated the relation of cardiac autonomic neuropathy (CAN) and other microangiopathies...
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The Role of Oxidative Stress in the Pathogenesis of Diabetic Vascular Complications

Sasaki S, Inoguchi T

Oxidative stress has been paid increasing attention to as an important causative factor for diabetic vascular complications. Among possible various sources, accumulating evidence has indicated that NAD(P)H oxidase may be...
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Reactive Oxygen and Nitrogen Species in Pathogenesis of Vascular Complications of Diabetes

Son SM

Macrovascular and microvascular diseases are currently the principal causes of morbidity and mortality in subjects with diabetes. Disorders of the physiological signaling functions of reactive oxygen species (superoxide and hydrogen...
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Kruppel-Like Factor 2 Suppression by High Glucose as a Possible Mechanism of Diabetic Vasculopathy

Lee HY, Youn SW, Oh BH, Kim HS

BACKGROUND AND OBJECTIVES: Endothelial dysfunction is widely observed in diabetes mellitus, resulting in diabetic vascular complications. Kruppel-like factor 2 (KLF2) is implicated as being a key molecule that maintains endothelial...
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New Perspectives on Diabetic Vascular Complications: The Loss of Endogenous Protective Factors Induced by Hyperglycemia

Jeong IK, King GL

Diabetic vascular complications are among the leading causes of morbidity and mortality in diabetic patients. In the past, many studies have focused on the mechanisms of hyperglycemia-induced chronic vascular complications...
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Klebsiella pneumoniae Orbital Cellulitis with Extensive Vascular Occlusions in a Patient with Type 2 Diabetes

Yang SJ, Park SY, Lee YJ, Kim HY, Seo JA, Kim SG, Choi DS

A 39-year-old woman visited the emergency room complaining of right eye pain and swelling over the preceding three days. The ophthalmologist's examination revealed orbital cellulitis and diabetic retinopathy in the...
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Potential role of HMG CoA reductase inhibitor on oxidative stress induced by advanced glycation endproducts in vascular smooth muscle cells of diabetic vasculopathy

Yoon SJ, Yoon YW, Lee BK, Kwon HM, Hwang KC, Kim M, Chang W, Hong BK, Lee YH, Park SJ, Min PK, Rim SJ

Advanced glycation endproducts (AGEs)-induced vascular smooth muscle cell (VSMCs) proliferation and formation of reactive oxygen species (ROS) are emerging as one of the important mechanisms of diabetic vasculopathy but little...
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Pathobiological role of advanced glycation endproducts via mitogen-activated protein kinase dependent pathway in the diabetic vasculopathy

Yoon YW, Kang TS, Lee BK, Chang W, Hwang KC, Rhee JH, Min PK, Hong BK, Rim SJ, Kwon HM

Advanced glycation endproducts (AGEs) have been reported to play a role in neointimal formation and increase the rate of in-stent restenosis (ISR) in the diabetic coronary artery disease patients treated...
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Migration of Vascular Smooth Muscle Cells by High Glucose is Reactive Oxygen Dependent

An YS, Kwon JH, Kang YH, Kim IJ, Kim YK, Son SM

BACKGROUND: Oxidative stress contributes to vascular diseases in patients with diabetes. As the mechanism of development and progression of diabetic vascular complications is poorly understood, this study was aimed to...
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The Effect of alpha-Lipoic Acid on Proteinuria and Renal TGFbeta Expression in Obese Type 2 Diabetic Rat Model

Kang SW, Lee SJ, Kim DS, Kim TW

BACKGROUND: It is well known that renal TGFbeta expression is related to the development of diabetic nephropathy. Alpha-lipoic acid (ALA), a potent antioxidant and cofactor of mitochondrial respiratory enzymes, can...
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