Korean J Anesthesiol.  1998 Oct;35(4):633-641. 10.4097/kjae.1998.35.4.633.

The Effects of Prostaglandin I2, Prostaglandin E1, and Nitroglycerin on Hemodynamics and Blood Gas Exchanges in Pulmonary Hypertension in Dogs

• Lee HH
• Yang MK
• Lim OH
• Lee SM
• Shin KI

• KMID: 2091300
• DOI: http://doi.org/10.4097/kjae.1998.35.4.633

Abstract

BACKGREOUND: The ideal drug for treatment of pulmonary hypertension would be a vasodilator which acts preferentially on the pulmonary vascular bed. The aim of this study was to compare the effects of prostaglandin I2 (PGI2) on central hemodynamics and right ventricular function with the more widely used vasodilators, prostaglandin E1 (PGE1) and nitroglycerin (NTG) and to investigate whether PGI2 is more selective to the pulmonary vascular bed compared with PGE1 and NTG in dogs.
METHODS
We have used a method for producing sustained pulmonary hypertension in vivo by continuous infusion of U46619 adjusting the infusion rate until a mean pulmonary artery pressure (PAP) exceeded 25 mmHg. And the pulmonary and systemic effects of the three pulmonary vasodilators were compared at doses producing equivalent, lowered approximately 20% of mean arterial pressures (MAP) or mean PAP returned to baseline.
RESULTS
After infusion of the three vasodilators, heart rate, cardiac output, and mean PAP/MAP ratio were significantly increased, but there was no statistical significant differences among the three vasodilators. PGI2 and PGE1 significantly increased (worsened) the PVR/SVR ratio, but NTG decreased. However there was no significant difference among the three vasodilators. After infusion of the three vasodilators, the arterial oxygen tension (PaO2), mixed venous oxygen tension (PO2), O2 deliver, and O2 uptake were increased, and shunt ratio (s/t(%)) were significantly decreased, but there were no significant differences among three vasodilators.
CONCLUSIONS
PGI2, PGE1, and NTG all decreased both PVR and SVR. None of these vasodilatorswere more selective to the pulmonary vascular bed, myocardial performance, and improved gas exchange.

Keyword

Blood Pressure:drug effect, pulmonary hypertension; Lung:oxygenation; Hormones: prostaglandin I2; prostaglandin E1; Pharmacology: nitroglycerin

MeSH Terms

15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Alprostadil*
Animals
Arterial Pressure
Cardiac Output
Dogs*
Epoprostenol*
Heart Rate
Hemodynamics*
Hypertension, Pulmonary*
Nitroglycerin*
Oxygen
Pulmonary Artery
Vasodilator Agents
Ventricular Function, Right
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Alprostadil
Epoprostenol
Nitroglycerin
Oxygen
Vasodilator Agents