- Impaired but reversible vascular reactivity in a rat model of microgravity
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Kim SY, Lim HK, Lee YB, Choi JC, Park JT, Ahn MC, Lee KH
- KMID: 2243002
- Korean J Anesthesiol.
- 2008 Nov;55(5):602-606.
- doi: 10.4097/kjae.2008.55.5.602
BACKGROUND: The hindlimb unweighting (HLU) rat model mimics cardiovascular deconditioning following microgravity or human bed rest, particularly for the development of orthostatic intolerance. We have examined vascular responses to alpha1... -
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- Propofol Attenuates Prostacyclin-induced Pulmonary Vasorelaxation in U46619 Preconstricted Dog
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Roh WS, Kim YJ, Jheon SH, Kim SO
- KMID: 2236724
- Korean J Anesthesiol.
- 2003 Aug;45(2):258-264.
- doi: 10.4097/kjae.2003.45.2.258
BACKGROUND: The goal of our study was to investigate the effects of propofol anesthesia on the pulmonary vascular response to prostacyclin during U46619 precontraction in dogs. METHODS: Eight mongrel... -
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- Influence of Thromboxane Aâ‚‚ on the Regulation of Adenosine Triphosphate-Sensitive Potassium Channels in Mouse Ventricular Myocytes
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Jeong IS, Cho HJ, Cho JG, Kim SH, Na KJ, Kim JK
- KMID: 2344433
- Korean Circ J.
- 2016 Jul;46(4):562-568.
- doi: 10.4070/kcj.2016.46.4.562
BACKGROUND AND OBJECTIVES: Adenosine triphosphate (ATP)-sensitive potassium (K(ATP)) channels play an important role in myocardial protection. We examined the effects of thromboxane Aâ‚‚ on the regulation of K(ATP) channel activity... -
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- The Relaxant Effect of Propofol on Isolated Rat Intrapulmonary Arteries
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Zhang G, Cui J, Chen Y, Ma J
- KMID: 2285535
- Korean J Physiol Pharmacol.
- 2014 Oct;18(5):377-381.
- doi: 10.4196/kjpp.2014.18.5.377
Propofol is a widely used anesthetic. Many studies have shown that propofol has direct effects on blood vessels, but the precise mechanism is not fully understood. Secondary intrapulmonary artery rings... -
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- The Effects of Prostacyclin Aerosol and Infusion on Pulmonary Hypertension
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Yang M, Lim OH, Lee HH, Shin B, Kim CS, Kim SD
- KMID: 2240125
- Korean J Anesthesiol.
- 1998 Sep;35(3):413-422.
- doi: 10.4097/kjae.1998.35.3.413
BACKGROUND: Prostacyclin administered intravenously has demonstrated intermediate pulmonary specificity and its aerosol form has an even greater pulmonary selectivity. There have been few systematic analyses of the difference in response... -
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- Requirement of Pretone by Thromboxane A2 for Hypoxic Pulmonary Vasoconstriction in Precision-cut Lung Slices of Rat
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Park SJ, Yoo HY, Kim HJ, Kim JK, Zhang YH, Kim SJ
- KMID: 2285441
- Korean J Physiol Pharmacol.
- 2012 Feb;16(1):59-64.
- doi: 10.4196/kjpp.2012.16.1.59
Hypoxic pulmonary vasoconstriction (HPV) is physiologically important response for preventing mismatching between ventilation and perfusion in lungs. The HPV of isolated pulmonary arteries (HPV-PA) usually require a partial pretone by... -
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- The Effects of Prostaglandin I2, Prostaglandin E1, and Nitroglycerin on Hemodynamics and Blood Gas Exchanges in Pulmonary Hypertension in Dogs
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Lee HH, Yang MK, Lim OH, Lee SM, Shin KI
- KMID: 2091300
- Korean J Anesthesiol.
- 1998 Oct;35(4):633-641.
- doi: 10.4097/kjae.1998.35.4.633
BACKGREOUND: The ideal drug for treatment of pulmonary hypertension would be a vasodilator which acts preferentially on the pulmonary vascular bed. The aim of this study was to compare the... -
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- Thromboxane A2 modulates migration, proliferation, and differentiation of adipose tissue-derived mesenchymal stem cells
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Yun DH, Song HY, Lee MJ, Kim MR, Kim MY, Lee JS, Kim JH
- KMID: 756282
- Exp Mol Med.
- 2009 Jan;41(1):17-24.
- doi: 10.3858/emm.2009.41.1.003
Prostanoid metabolites are key mediators in inflammatory responses, and accumulating evidence suggests that mesenchymal stem cells (MSCs) can be recruited to injured or inflamed tissues. In the present study, we... -
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- Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway
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Baek I, Jeon SB, Song MJ, Yang E, Sohn UD, Kim IK
- KMID: 2071672
- Korean J Physiol Pharmacol.
- 2009 Jun;13(3):201-207.
- doi: 10.4196/kjpp.2009.13.3.201
Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1). In the present study, we hypothesized that flavone attenuates vascular... -
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- The vasorelaxatory effect of the milrinone on the preconstricted rat aorta
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Kwon HU, Park JT, Ryoo S, Park IH, Lee SH, Kim SY, Yoon SH, Lim HK
- KMID: 2092249
- Korean J Anesthesiol.
- 2009 Nov;57(5):615-621.
- doi: 10.4097/kjae.2009.57.5.615
BACKGROUND: Milrinone, phosphodiesterase III inhibitor, has been used effectively in patients with right heart failure, especially resulted from pulmonary hypertension. However, milrinone is often used with alpha- and beta-adrenergic receptor... -
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- Changes in cytosolic Ca2+ but not in cGMP contents may be more important to nitric oxide-mediated relaxation in depolarized vascular smooth muscle
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Lee HS, Chang KC
- KMID: 2071525
- Korean J Physiol Pharmacol.
- 1998 Feb;2(1):63-68.
Nitric oxide (NO)-mediated relaxation in vascular smooth muscle involves not only activation of guanylate cyclase but also hyperpolarization of the membrane. It has been shown that depolarization decreases the (Ca2+) sensitivity of myosin... -
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- The relaxing effect of Poncirus fructus and its flavonoid content on porcine coronary artery
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Yu DJ, Jun JH, Kim TJ, Suh DK, Youn DH, Kim TW
- KMID: 1787649
- Lab Anim Res.
- 2015 Mar;31(1):33-39.
- doi: 10.5625/lar.2015.31.1.33
Coronary artery disease is a common occurrence in human, and causes enormous social cost. Poncirus fructus (PF), the dried immature fruits of Poncirus trifoliata Rafinesquem, is used in the treatment... -
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- The bifunctional effect of propofol on thromboxane agonist (U46619)-induced vasoconstriction in isolated human pulmonary artery
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Hao N, Zhaojun W, Kuang S, Zhang G, Deng C, Ma J, Cui J
- KMID: 2395253
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):591-598.
- doi: 10.4196/kjpp.2017.21.6.591
Propofol is known to cause vasorelaxation of several systemic vascular beds. However, its effect on the pulmonary vasculature remains controversial. In the present study, we investigated the effects of propofol... -
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- In Vitro Effects of Nitroglycerin, Nicardipine, Verapamil, and Papaverine on Rabbit Brachial and Celiac Arterial Tone
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Shinn SH, Kim YH, Seo JK, Kim JH, Chung WS, Jeon YB, Chang BC, Jang HJ
- KMID: 2289174
- Korean J Thorac Cardiovasc Surg.
- 2008 Oct;41(5):541-549.
BACKGROUND: Vasoconstrictor-induced reduction in arterial graft diameter can cause significant flow deprivation. The aim of this study was to evaluate the effect of vasodilator pretreatment on vasoconstrictor-induced blood vessel spasm... -
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- Effect of Estrogen Replacement on Vascular Responsiveness in Ovariectomized Spontaneously Hypertensive Rat
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Seo B, Choi DJ, Hwang JY, Cheon IS, Lee YP
- KMID: 2227381
- Korean Circ J.
- 2000 Apr;30(4):528-528.
- doi: 10.4070/kcj.2000.30.4.528
BACKGROUND: Although postmenopausal estrogen replacement therapy is known to reduce cardiovascular mortality, the mechanism is not clear yet. Furthermore, the effect of estrogen on vascular tonus is reportedly variable according... -
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- Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice
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Shin W, Berkowitz , Ryoo S
- KMID: 1506223
- Exp Mol Med.
- 2012 Oct;44(10):594-602.
The incidence of cardiovascular disease is predicted to increase as the population ages. There is accumulating evidence that arginase upregulation is associated with impaired endothelial function. Here, we demonstrate that... -
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