Korean J Anesthesiol.  1993 Oct;26(5):852-862. 10.4097/kjae.1993.26.5.852.

Effects of Dobutamine and Prostaglandin E 1 on Pulmonary Capillary Pressure and Arterial Oxygenation in a Canine Model of Endotoxin - induced ARDS

• Choi KT

• KMID: 1690040
• DOI: http://doi.org/10.4097/kjae.1993.26.5.852

Abstract

The effects of treatment of endotoxin-induced ARDS with dobutamine and prostaglandin E 1 on cardiopulmonary function in five dogs were investigated. Pulmonary arterial wedge pressure was adjusted to a baseline value. E. Coli endotoxin (055: B5, Sigma) infusion (3 mg/kg) resulted in an abrupt increase of pulmonary arterial and pulmonary capillary pressure while systemic blood pressure gradually fell. Cardiac output decreased. Systemic vascular resistance decreased and pulmonary vascular resistance increased. Experimental ARDS was developed approximately three hours after the endotoxin infusion. Dobutamine (5 ug/kg/min) increased cardiac output (p<0.05) but pulmonary capillary pressure did not decrease. Pulmonary vascular resistance decreased (p<0.05). PaO2 and Qs/Qt did not change significantly. Prostaglandin E 1 (0.4 ug/kg/min) with dobutamine decreased pulmonary arterial pressure (p<0.05) and pulmonary capillary pressure (p=N.S.), pulmonary vascular resistance (p<0.05). Arterial oxygenation did not improve but oxygen extraction ratio increased significantly. We concluded that prostaglandin E 1 with dobutamine improved tissue oxygen uptake in endotoxin-induced ARDS.

Keyword

Endotoxin; ARDS; Dobutamine; Prostaglandin E1; Pulmonary capillary pressure

MeSH Terms

Alprostadil
Animals
Arterial Pressure
Blood Pressure
Capillaries*
Cardiac Output
Dobutamine*
Dogs
Oxygen*
Pulmonary Wedge Pressure
Vascular Resistance
Alprostadil
Dobutamine
Oxygen