Korean J Urol.  1999 Nov;40(11):1536-1539.

Are There Clinical Factors Relating to Penile Pain associated with Intracavernous Injection of Prostaglandin E1 in Patients with Erectile Dysfunction?

• Han CK
• Chung WS

Abstract

PURPOSE: We performed this study to identify the factors relating to penile pain after intracavernosal injection of prostaglandin E1.
MATERIALS AND METHODS
We studied 116 patients with erectile dysfunction, who were evaluated by color duplex ultrasonography after intracavernosal injection of prostaglandin E1. Flow parameters and several clinical factors including age, the presence of vascular risk factors, and the severity or duration of erectile dysfunction were compared according to the degree of pain after intracavernosal injection.
RESULTS
Most of patients (79% of total) receiving intracavernosal injections felt penile pain, and severe pain interfering with sexual activity was reported by 27% of patients. We could not find any clinical factor that correlated with the pain, nor was there a consistent association of pain with any particular hemodynamic parameter of the penis (p>0.05).
CONCLUSIONS
The pain developing after intracavernosal injection of prostaglandin E1 might be related to individual tissue or receptor properties of the penile cavernous tissue.

Keyword

Penile pain; Prostaglandin E1; Erectile dysfunction

MeSH Terms

Alprostadil*
Erectile Dysfunction*
Hemodynamics
Humans
Male
Penis
Risk Factors
Sexual Behavior
Ultrasonography
Alprostadil