Korean J Urol.  1997 Apr;38(4):422-426.

Erectile Response to Intracavernous Injection of Prostaglandin E1 or Papaverine in Impotence Patients with Diabetes Mellitus

• Kim WB
• Seo KK
• Kim SC

Abstract

PURPOSE: To assess the erectile response to intracavernous injection of prostaglandin E1 (PGE 1) or papaverine in the impotence patients with diabetes mellitus (DM), and to determine the factors which would predict good response to either drug.
MATERIALS AND METHODS
We injected papaverine (10~60 mg) or PGE1 (10~20 mg) into cavernosal tissues of 305 impotence patients with DM (mean age; 56.1 years). Erectile response was classified into poor, moderate, or good, and was comparatively analyzed according to kinds of vasoactive agents, patients` age, duration of DM and impotence, and treatment modality of DM.
RESULTS
The frequency of good response to PGE1 was significantly higher than to papaverine (61.5% vs. 42.8%; p<0.05). However, no association between erectile response and patients` age, duration of impotence and DM, and treatment modality of DM was noted.
CONCLUSIONS
Prostaglandin E1 seems to be more effective substance than papaverine for intracavernous injection therapy in impotence patients with DM.

Keyword

prostaglandin E1; papaverine; erectile response

MeSH Terms

Alprostadil*
Diabetes Mellitus*
Erectile Dysfunction*
Humans
Male
Papaverine*
Alprostadil
Papaverine